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Nevirapine resistance and breast-milk HIV transmission: effects of single and extended-dose nevirapine prophylaxis in subtype C HIV-infected infants.

Author: BalasubramaniamUsha, BharadwajRenu, BhoreArvind V, BhosaleRamesh, BollingerRobert, GuptaAmita, GupteNikhil, KagalAnju, KulkarniSmita, KulkarniVandana, MoorthyAnitha, PatilSandesh, PersaudDeborah, SastryJayagowri, SuryavanshiNishi, ThakarMadhuri, TripathySrikanth, VenkataramaniVaradharajan, ZiemniakCarrie

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study assessed nevirapine resistance in Indian infants enrolled in a trial for prevention of breast-milk HIV transmission. Results showed that NVP-resistance was detected in infants who acquired subtype C HIV infection despite receiving single-dose or extended-dose nevirapine.
Paper Details　
Original Abstract of the Article :
Daily nevirapine (NVP) prophylaxis to HIV-exposed infants significantly reduces breast-milk HIV transmission. We assessed NVP-resistance in Indian infants enrolled in the "six-week extended-dose nevirapine" (SWEN) trial who received single-dose NVP (SD-NVP) or SWEN for prevention of breast-milk HIV ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2606064/

データ提供：米国国立医学図書館（NLM）

Nevirapine Resistance: A Challenge to HIV Prevention

The fight against HIV/AIDS is a constant struggle, much like navigating a vast desert in search of a life-giving oasis. This study, conducted in India, examined the challenge of nevirapine (NVP) resistance in HIV-infected infants who received single-dose NVP (SD-NVP) or extended-dose nevirapine (SWEN) prophylaxis to prevent breast-milk HIV transmission. The authors analyzed the prevalence of NVP resistance in infants who acquired subtype C HIV infection during the first year of life, shedding light on the complexities of HIV prevention in this vulnerable population.

Understanding NVP Resistance

This study provides important insights into the development of NVP resistance in HIV-infected infants. The authors found that NVP resistance was a significant concern in infants who acquired HIV infection, regardless of the prophylactic regimen they received. This finding emphasizes the need for continued research and development of new HIV prevention strategies.

Improving HIV Prevention for Infants

The fight against HIV/AIDS requires ongoing innovation and adaptation. This study highlights the importance of developing new HIV prevention strategies, particularly for infants. The authors' findings underscore the need for continued research to address the challenges of NVP resistance and to ensure the effectiveness of HIV prevention programs.

Dr.Camel's Conclusion

This research, like a beacon in the desert, sheds light on the ongoing challenges of HIV prevention. It emphasizes the need for continued research and development to combat the ever-evolving nature of this global health crisis.

Date :
  1. Date Completed 2009-02-04
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19119321

DOI: Digital Object Identifier

PMC2606064

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・Effects of nevirapine
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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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