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Antitumor effects of ketoconazole and trifluoperazine in murine T-cell lymphomas.

Author: EilamY, NaftalovichS, YefenofE

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ketoconazole, trifluoperazine, and their combinations showed antitumor activity against T-cell lymphomas in mice. Both drugs, alone and in combination, delayed tumor growth, reduced tumor size, and prolonged survival.
Paper Details　
Original Abstract of the Article :
In vitro and in vivo antitumor effects of ketoconazole (KTZ), trifluoperazine (TFP), and combinations of both drugs were examined in cell lines established from radiation leukemia virus (RadLV)-induced T-cell lymphomas. KTZ inhibited [3H]-thymidine incorporation in the tumor cells in vitro; 50% inhi...See full text at original site
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引用元：
https://doi.org/10.1007/BF00685694

データ提供：米国国立医学図書館（NLM）

Ketoconazole and Trifluoperazine: A Novel Approach to T-Cell Lymphoma Treatment

T-cell lymphomas, like a relentless desert storm, can wreak havoc on the immune system. This study explores the potential of ketoconazole (KTZ) and trifluoperazine (TFP) as novel therapeutic agents for treating these aggressive cancers.

Combating the Desert Storm of Lymphoma

The researchers found that KTZ and TFP, both individually and in combination, inhibited the growth of T-cell lymphoma cells in vitro and in vivo. These findings suggest that these drugs may hold promise as new treatment options for T-cell lymphomas.

Expanding the Arsenal Against Lymphoma

This study offers a potential new avenue for treating T-cell lymphomas, potentially providing a more effective and targeted approach to combating this challenging disease.

Dr.Camel's Conclusion

The quest for effective treatments for T-cell lymphomas continues, and this study offers a promising lead. By exploring the potential of KTZ and TFP, we may be able to develop new strategies for combating this aggressive cancer and providing hope to patients facing this difficult journey.

Date :
  1. Date Completed 1991-10-30
  2. Date Revised 2019-08-28
Further Info :

Pubmed ID

1914083

DOI: Digital Object Identifier

10.1007/BF00685694

Related Literature

Article Analysis
・Effects of trifluoperazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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