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Treatment for familial amyotrophic lateral sclerosis/motor neuron disease.

Author: BenatarMichael, KurentJerome, MooreDan H

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Amyotrophic lateral sclerosis (ALS), also called motor neuron disease (MND), is a rare neurological disease. About 5-7% of people with ALS/MND have a family history of the disease. A gene mutation is responsible for about 20% of familial cases. The cause of ALS/MND in people without a family history is unknown, as is whether people with familial and non-familial ALS/MND respond differently to treatment.
Paper Details　
Original Abstract of the Article :
Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a rare neurodegenerative disease. Approximately 5% to 7% of ALS/MND patients report a family history of a similarly affected relative. Superoxide dismutase-1 gene mutations are the cause in about 20% of familial cases....See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388919/

データ提供：米国国立医学図書館（NLM）

Seeking Answers: The Puzzle of Familial Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is a debilitating neurodegenerative disorder. This study explores the complexities of ALS, focusing on the familial form of the disease, where a family history of ALS is present. It delves into the genetic basis of familial ALS, highlighting the role of mutations in the superoxide dismutase-1 gene. It's like investigating the secrets of a hidden oasis, searching for the underlying causes of this devastating disease.

Unlocking the Mysteries: Exploring Familial and Sporadic ALS

The study investigates the differences between familial and sporadic ALS, highlighting the potential for distinct responses to treatment. It sheds light on the genetic basis of familial ALS, revealing the role of superoxide dismutase-1 gene mutations in a significant proportion of cases. This research is like uncovering ancient inscriptions, revealing clues about the underlying mechanisms of this complex disease.

A Call for Further Research: Understanding and Treating ALS

This study underscores the need for further research into the causes and treatment of ALS, both familial and sporadic. It's like mapping a vast desert, uncovering new pathways to understanding and treating this debilitating disease. By exploring the differences between these two forms of ALS, researchers can develop more targeted and effective treatments, bringing hope to those affected by this challenging condition.

Dr.Camel's Conclusion

This research sheds light on the complex nature of ALS, highlighting the need for further investigation to understand the differences between familial and sporadic forms of the disease. It's like navigating a desert filled with hidden oases, each requiring a unique approach to discovery. By unlocking the secrets of ALS, we can pave the way for more effective treatments and a brighter future for those affected by this devastating disease.

Date :
  1. Date Completed 2009-03-19
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19160266

DOI: Digital Object Identifier

PMC7388919

SNS
PICO Info
in preparation
Languages

English

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