Asenapine exerts distinctive regional effects on ionotropic glutamate receptor subtypes in rat brain.

Author: ChoiYong Kee, GardnerMatthew, HenryBrian, ShahidMohammed, TaraziFrank I, WongErik H F

Paper Details 
Original Abstract of the Article :
Asenapine, a new pyschopharmacologic agent being developed for the treatment of schizophrenia and bipolar disorder, has a unique human receptor binding signature with strong affinity for dopaminergic, alpha-adrenergic, and, in particular, serotonergic receptors raising the possibility of interaction...See full text at original site
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引用元:
https://doi.org/10.1002/syn.20618

データ提供:米国国立医学図書館(NLM)

Asenapine: Regional Effects on Ionotropic Glutamate Receptors

The field of [Neuroscience] is always exploring the mechanisms of [Neurotransmission] and [Psychopharmacology]. This research examines the effects of [Asenapine], a new [Psychotropic] agent, on [Ionotropic Glutamate Receptors] in different regions of the [Rat Brain]. The authors used [Repeated Administration] of [Asenapine] to assess its impact on [NMDA Receptor] and [AMPA Receptor] binding in various brain regions. Their findings suggest that [Asenapine] exhibits [Region-Specific] and [Dose-Dependent] effects on these receptors. The study found that [Asenapine] significantly reduced [NMDA Receptor] binding in [Nucleus Accumbens] and [Caudate Putamen], while increasing [AMPA Receptor] binding in the [Hippocampus]. This research provides a valuable understanding of the [Neuropharmacological] mechanisms of [Asenapine] and its potential impact on [Neurotransmission] in different brain regions.

Asenapine: A Novel Psychotropic Agent with Regional Specificity

This research reveals the unique [Neuropharmacological] profile of [Asenapine]. The study's findings suggest that [Asenapine] exerts different effects on [Glutamate Receptors] in different brain regions, highlighting the complexity of [Neurotransmission] and the potential for region-specific therapeutic applications. Further research is needed to fully understand the implications of these findings for [Psychopharmacology].

Exploring the Brain: A Journey Through a Complex Landscape

The [Brain] is a complex organ with intricate pathways and delicate balances. This research highlights the importance of understanding the [Neuropharmacological] mechanisms of drugs like [Asenapine] to ensure safe and effective treatment. Remember, the [Brain] is a delicate organ that requires careful consideration when it comes to [Medication Use].

Dr. Camel's Conclusion

The desert of [Neuroscience] is vast and filled with mysteries. This research provides a glimpse into the complex world of [Neurotransmission] and the potential impact of drugs like [Asenapine] on [Brain Function]. Just as a camel navigates the shifting sands, we must carefully consider the potential effects of [Psychotropic] medications on our [Brain] and seek guidance from healthcare professionals for optimal well-being. Remember, the brain is a precious organ that deserves our utmost care and attention.

Date :
  1. Date Completed 2009-06-17
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

19177511

DOI: Digital Object Identifier

10.1002/syn.20618

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Languages

English

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