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MQX-503, a novel formulation of nitroglycerin, improves the severity of Raynaud's phenomenon: a randomized, controlled trial.

Author: BaronMurray, ChungLorinda, CollierDavid, CsukaM E, DechowFrederick J, FiorentinoDavid, GilbertAdam, GregoryJeffrey, GruberBarry, HsuVivien, KahalehBashar, MartinRichard W, MayesMaureen, PopeJanet, RothfieldNaomi, ShanahanJoseph, ShapiroLee, SimmsRobert, SmithEdwin, SteenVirginia, SuleSangeeta, SweissNadera, WigleyFredrick M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Raynaud's phenomenon (RP) affects 3-9% of the general population and >90% of patients with systemic sclerosis. Nitrates are often prescribed for RP treatment, but current formulations are limited by side effects such as headaches, dizziness, and skin irritation. This study aimed to evaluate the tolerability and efficacy of a novel topical nitroglycerin formulation, MQX-503, in treating RP in an ambulatory setting.
Paper Details　
Original Abstract of the Article :
Raynaud's phenomenon (RP) affects 3-9% of the general population and >90% of patients with systemic sclerosis. Nitrates are often prescribed for the treatment of RP, but currently available formulations are limited by side effects, particularly headaches, dizziness, and skin irritation. The purpose ...See full text at original site
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引用元：
https://doi.org/10.1002/art.24351

データ提供：米国国立医学図書館（NLM）

MQX-503, a Novel Formulation of Nitroglycerin, for Raynaud's Phenomenon

This research study takes us into the world of vascular disorders, exploring the use of a novel formulation of nitroglycerin, MQX-503, for the treatment of Raynaud's phenomenon (RP). The study, like a skilled researcher navigating the intricate pathways of blood flow, explores the potential of MQX-503 to provide relief for patients with RP, a condition that can cause painful and debilitating episodes of vasoconstriction. The research seeks to find a safer and more effective treatment option for RP, a condition that can feel like a cold desert wind sweeping through the body.

Finding Relief from the Cold Winds of Raynaud's

The study found that MQX-503 was effective in reducing the severity of Raynaud's phenomenon, offering a potential alternative to traditional nitroglycerin formulations. This finding is like discovering a new oasis in the desert of Raynaud's treatment, providing a more comfortable and effective path to relief for patients.

Warming Up to a New Treatment Approach

The study highlights the importance of ongoing research into new treatment options for Raynaud's phenomenon. This research provides valuable insights for developing more effective and tolerable treatments, helping patients manage their symptoms and find a path to a warmer and more comfortable life.

Dr. Camel's Conclusion

The study reminds us that even in the face of cold and debilitating conditions like Raynaud's, there is hope for relief. This research offers a promising new approach for treating this vascular disorder, providing a glimmer of warmth in the desert of Raynaud's.

Date :
  1. Date Completed 2009-04-27
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19248104

DOI: Digital Object Identifier

10.1002/art.24351

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Article Analysis
・Side Effects of nitroglycerin topical
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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