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Ginkgo biloba extract enhances antiplatelet and antithrombotic effects of cilostazol without prolongation of bleeding time.

Author: ChungJin-Ho, HanHye Young, ImGuang-Jin, JeonSun Duck, KimKeunyoung, LeeBong Yong, LeeSo Young, LimKyung-Min, RyuKeun Ho

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Cilostazol and Ginkgo biloba extract (GB) are both used to treat peripheral arterial disease by inhibiting platelet aggregation. This study found that combining GB with cilostazol resulted in enhanced antiplatelet activity in vitro and in vivo, potentially offering more effective treatment for peripheral occlusive vascular diseases without increasing bleeding risk.
Paper Details　
Original Abstract of the Article :
Thrombosis and thromboembolic occlusions of major and minor blood vessels are a major complication in various peripheral vascular diseases. Antiplatelet agents (APA), key tools in the treatment of atherothrombosis, therefore became a mainstay medication for a wide range of vascular diseases. Cilosta...See full text at original site
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引用元：
https://doi.org/10.1016/j.thromres.2009.02.010

データ提供：米国国立医学図書館（NLM）

Ginkgo Biloba Extract and Cilostazol for Thrombosis

This study investigates the potential benefits of combining Ginkgo biloba extract (GB) with cilostazol, two agents used to prevent blood clots (thrombosis). Imagine a camel traversing a desert landscape, its path potentially blocked by sandstorms (thrombosis). This study explores whether combining two 'anti-sandstorm' agents can provide better protection. The researchers found that combining GB and cilostazol enhanced their antiplatelet and antithrombotic effects, effectively reducing the risk of clots in both in vitro and in vivo models.

A Powerful Alliance Against Thrombosis

The study highlights the potential of combining GB and cilostazol to enhance antithrombotic efficacy. It's like finding a powerful alliance of desert warriors, each with unique skills, working together to overcome a common enemy. The study's findings suggest that this combination therapy could offer a promising approach to preventing thrombosis and improving patient outcomes.

Keeping the Blood Flowing Through the Desert

This research underscores the importance of exploring new combinations of medications to combat thrombosis. By combining agents with complementary mechanisms of action, scientists can create synergistic effects, providing more effective and targeted therapies. It's a reminder that collaboration and innovation are essential in the fight against health challenges.

Dr. Camel's Conclusion

This study demonstrates the potential of combining GB and cilostazol to enhance antithrombotic efficacy, offering a promising approach to preventing thrombosis. It's a reminder that we should be open to exploring new combinations of therapies and embracing innovative solutions to address health challenges.

Date :
  1. Date Completed 2009-09-30
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

19349067

DOI: Digital Object Identifier

10.1016/j.thromres.2009.02.010

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Article Analysis
・Side Effects of cilostazol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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