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Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity.

Author: AlexopoulosLeonidas G, CosgroveBenjamin D, FaraziParaskevi A, GriffithLinda G, HasanMaya A, HendriksBart S, KingBracken M, LauffenburgerDouglas A, SorgerPeter K, TidorBruce, XuJinghai J

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study presents a high-throughput in vitro approach for investigating drug-induced hepatotoxicity. It uses a combination of drug and cytokine treatments to mimic inflammatory conditions and identify drug-cytokine synergies, potentially leading to better preclinical screening methods for idiosyncratic drug hepatotoxicity.
Paper Details　
Original Abstract of the Article :
Idiosyncratic drug hepatotoxicity represents a major problem in drug development due to inadequacy of current preclinical screening assays, but recently established rodent models utilizing bacterial LPS co-administration to induce an inflammatory background have successfully reproduced idiosyncratic...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/19362101

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2009-06-18
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19362101

DOI: Digital Object Identifier

NIHMS109196

SNS
PICO Info
in preparation
Languages

English

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