Paper Details

  1. Home
  2. Paper Details

Effects of first-line use of nucleoside analogues, efavirenz, and ritonavir-boosted protease inhibitors on lipid levels.

Author: GazzardBrian, HillAndrew, SawyerWill

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

There is a wide range of lipid elevations during 48 weeks of first-line HAART, depending on the choice of antiretrovirals used.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Treatment with ritonavir-boosted protease inhibitors or efavirenz and nucleoside analogues leads to rises in lipids, which might contribute to cardiovascular risk. METHOD: A MEDLINE search for clinical trials of first-line HAART with standardized 48-week lipids data available for comb...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1310/hct1001-001

データ提供：米国国立医学図書館（NLM）

HIV Treatment and Lipids: A Balancing Act in the Desert of Health

HIV treatment has advanced significantly, but it can have unintended consequences, particularly on lipid levels. This study investigates the effects of various first-line antiretroviral treatments on lipid levels, analyzing data from 15 clinical trials. The authors aim to identify the specific antiretroviral combinations that are most likely to lead to changes in lipid levels.

Navigating the Shifting Sands of Lipids

The study reveals that different antiretroviral combinations have varying effects on lipid levels. The authors found that protease inhibitors, particularly those boosted with ritonavir, led to significant increases in total cholesterol and triglycerides. Efavirenz also contributed to elevated lipid levels. Notably, the study highlights the importance of choosing antiretroviral regimens that minimize lipid disturbances, particularly for individuals at risk for cardiovascular disease.

A Balance Between Treatment and Health

This study underscores the importance of carefully monitoring lipid levels in individuals undergoing HIV treatment. It's like navigating a desert landscape where the path to optimal health requires a delicate balance. The study provides valuable insights for healthcare professionals to help patients manage their lipid levels and minimize the risk of cardiovascular complications.

Dr. Camel's Conclusion

HIV treatment, much like a desert caravan, requires careful planning and navigation. This study offers valuable insights into the potential impact of different antiretroviral combinations on lipid levels, emphasizing the importance of individualizing treatment plans to minimize the risk of long-term health complications.

Date :
  1. Date Completed 2009-07-02
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

19362991

DOI: Digital Object Identifier

10.1310/hct1001-001

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.