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Comparative neuroprotective effects of rasagiline and aminoindan with selegiline on dexamethasone-induced brain cell apoptosis.

Author: JohnsonChandra, JohnsonShakevia, LuDeyin, OuXiao-Ming, StockmeierCraig A, TazikShawna, YoudimMoussa B H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Rasagiline, an MAO B inhibitor, showed the highest neuroprotective effect against dexamethasone-induced brain cell death compared to selegiline and its metabolite, 1-R-aminoindan, suggesting its potential for treating stress-related depression.
Paper Details　
Original Abstract of the Article :
Stress can affect the brain and lead to depression; however, the molecular pathogenesis is unclear. An association between stress and stress-induced hypersecretion of glucocorticoids occurs during stress. Dexamethasone (a synthetic glucocorticoid steroid) has been reported to induce apoptosis and in...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/19384601

データ提供：米国国立医学図書館（NLM）

Rasagiline: A Potential Protector Against Stress-Induced Brain Cell Death

This research investigates the neuroprotective effects of rasagiline, a drug used to treat Parkinson's disease, against stress-induced brain cell death. The study compared the neuroprotective abilities of rasagiline, its metabolite R-aminoindan, and selegiline, another MAO inhibitor, using human neuroblastoma cells. The results demonstrate that rasagiline exhibited the highest neuroprotective effect, potentially offering a new approach to mitigating stress-induced brain damage.

Rasagiline: A Shield Against the Desert Storm of Stress

This research offers a valuable insight into the potential of rasagiline in mitigating the effects of stress on the brain. It's like finding a powerful shield against a desert storm, protecting brain cells from the damaging effects of stress. The study's findings suggest that rasagiline may play a role in reducing stress-induced brain cell death, potentially contributing to improved cognitive function and overall well-being.

Stress and the Brain: A Journey Through the Desert

This research underscores the importance of understanding and mitigating the effects of stress on the brain. It's like navigating a challenging desert landscape, where the right tools and strategies are crucial for survival. The study's findings suggest that rasagiline may offer a promising avenue for protecting brain cells from the damaging effects of stress, potentially leading to a more resilient and adaptable brain.

Dr. Camel's Conclusion

This research provides a fascinating look into the potential of rasagiline in protecting brain cells from the damaging effects of stress. It's like finding a hidden oasis in the vast desert of stress research, offering a glimmer of hope for those seeking ways to mitigate the detrimental effects of stress on the brain.

Date :
  1. Date Completed 2010-01-08
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19384601

DOI: Digital Object Identifier

NIHMS105008

Related Literature

Article Analysis
・Effects of rasagiline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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