Paper Details
- Home
- Paper Details
Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in beagle dog left ventricular midmyocardial myocytes.
Author: Abi-GergesNajah, Bridgland-TaylorMatthew, HardyMatthew E L, PollardChris E, SmallBen G, ValentinJean-Pierre, WoodsAnn J
Original Abstract of the Article :
Evaluation of drug candidates in in-vitro assays of action potential duration (APD) is one component of preclinical safety assessment. Current assays are limited by technically-demanding, time-consuming electrophysiological methods. This study aimed to assess whether a voltage-sensitive dye-based as...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1016/j.vascn.2009.03.005
データ提供：米国国立医学図書館（NLM）
Assessing Drug-Induced Delayed Repolarization: A New Approach Using Voltage-Sensitive Dye
Drug development is a complex process that involves rigorous safety testing. One crucial aspect of safety assessment is the evaluation of potential drug-induced effects on heart rhythm. This study explores a new method for assessing drug-induced delayed repolarization using a voltage-sensitive dye (di-4-ANEPPS) in beagle dog left ventricular midmyocardial myocytes. The research aims to determine the feasibility of using this dye-based assay as an alternative to traditional electrophysiological methods for assessing drug effects on cardiac repolarization.
A New Tool for Drug Safety Assessment: Dye-Based Assay for Delayed Repolarization
The study demonstrates the potential of using a voltage-sensitive dye-based assay to assess drug-induced delayed repolarization in isolated myocytes. This research offers a promising alternative to traditional electrophysiological methods, potentially simplifying and streamlining the drug safety assessment process. This advancement can contribute to the development of safer and more effective drugs, ensuring the well-being of patients.
From the Lab to the Clinic: Improving Drug Safety
The development of new drug safety assessment methods, such as the voltage-sensitive dye-based assay, is crucial for ensuring the safety and efficacy of new drugs. This research highlights the importance of ongoing innovation in drug safety testing, paving the way for a more efficient and effective drug development process. Just as a desert traveler relies on advanced tools and techniques to navigate their journey, researchers are constantly seeking to improve drug safety testing methods.
Dr.Camel's Conclusion
This study explores the potential of a voltage-sensitive dye-based assay as a promising alternative to traditional electrophysiological methods for assessing drug-induced delayed repolarization. The findings suggest that this dye-based assay can provide a valuable tool for streamlining drug safety assessment, leading to the development of safer and more effective drugs.
Date :
- Date Completed 2010-01-12
- Date Revised 2014-11-20
Further Info :
Related Literature
English
This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.