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Avidin fusion protein-expressing lentiviral vector for targeted drug delivery.

Author: AirenneKari J, KaikkonenMinna U, Lehtolainen-DalkilicPauliina, LeschHanna P, MäättäAnn-Marie, PikkarainenJere T, SamaranayakeHaritha, TaavitsainenMiia, VuorioTaina, WirthThomas, Ylä-HerttualaSeppo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A lentiviral vector expressing a fusion protein of avidin and the endocytotic part of the low-density lipoprotein receptor was shown to be safe and effective in targeting cytotoxic compounds to cancer cells.
Paper Details　
Original Abstract of the Article :
One of the main objectives of cancer therapy is to enhance the effectiveness of the drug by concentrating it at the target site and to minimize the undesired side effects to nontarget cells. We have previously constructed a fusion protein, Lodavin, consisting of avidin and the endocytotic part of th...See full text at original site
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引用元：
https://doi.org/10.1089/hum.2009.007

データ提供：米国国立医学図書館（NLM）

Targeting Cancer Cells with Precision

Cancer treatment is a complex and challenging field, much like navigating a vast desert filled with obstacles and dangers. This study explored a new approach for delivering cancer drugs directly to tumor cells, reducing the risk of harming healthy tissues. The researchers developed a lentiviral vector that expresses an avidin fusion protein, creating a targeted delivery system for biotinylated drugs. This approach is like using a caravan to transport supplies to a specific oasis, ensuring that the resources are delivered directly to their intended destination.

A Precise Approach to Cancer Treatment

The study demonstrated that the lentiviral vector effectively delivered the avidin fusion protein to glioma cells, allowing for the targeted delivery of biotinylated drugs. This strategy offers a promising new approach for treating cancer, one that could potentially enhance treatment efficacy and reduce side effects. It's like finding a more efficient and safer route through the desert of cancer treatment.

Navigating the Challenges of Cancer Therapy

This research represents a significant step forward in the development of targeted cancer therapies. By delivering drugs directly to tumor cells, researchers are working towards a more precise and effective approach to cancer treatment. It's like creating a more precise and efficient map for navigating the challenges of cancer therapy.

Dr.Camel's Conclusion

This study provides a promising new avenue for treating cancer, one that could potentially revolutionize the way we approach this devastating disease. By targeting cancer cells with precision, researchers are working towards a future where cancer treatment is more effective and less burdensome for patients. It's a journey of hope in the desert of cancer research, one that promises a brighter future for those affected by this disease.

Date :
  1. Date Completed 2009-10-07
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19419273

DOI: Digital Object Identifier

10.1089/hum.2009.007

SNS
PICO Info
in preparation
Languages

English

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