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Gulf War illness: Effects of repeated stress and pyridostigmine treatment on blood-brain barrier permeability and cholinesterase activity in rat brain.

Author: AmouretteChristine, BarbierLaure, DiserboMichel, FauquetteWilliam, LamproglouIoannis, ViretRoselyne, ZoppeAmélie

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found no evidence of pyridostigmine crossing the blood-brain barrier in rats subjected to repeated stress. This suggests that pyridostigmine’s central effects under stress may be mediated by indirect mechanisms originating from a peripheral pathway.
Paper Details　
Original Abstract of the Article :
After the first Persian Gulf War, many soldiers have complained of a variety of symptoms designated as "Gulf War Illness". Among several factors, implication of pyridostigmine (PB) in late cognitive dysfunction is highly likely. As a hypothesis to explain these behavioural disorders is a potentiatio...See full text at original site
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引用元：
https://doi.org/10.1016/j.bbr.2009.05.002

データ提供：米国国立医学図書館（NLM）

Gulf War Illness: A Desert of Unanswered Questions

Gulf War Illness, a mysterious condition that affects many veterans, is like a desert mirage, elusive and challenging to understand. This research investigates the potential role of repeated stress and pyridostigmine treatment in the development of this illness, like exploring the desert for clues to the cause of a mysterious phenomenon. The study investigates the effects of these factors on the blood-brain barrier and cholinesterase activity in rat brains, seeking to understand the underlying mechanisms of Gulf War Illness.

A Mysterious Desert Trail

The research explores the potential link between repeated stress, pyridostigmine treatment, and brain function. The study finds that while pyridostigmine may have central effects, it does not seem to cross the blood-brain barrier in this experimental model. This finding suggests that the effects of pyridostigmine may be indirect, like a hidden desert trail that leads to a different destination.

The Importance of Continued Exploration

This research underscores the importance of continued exploration in understanding the causes and mechanisms of Gulf War Illness. The desert of this mysterious condition is vast and complex, and we must continue to search for answers to alleviate the suffering of those affected.

Dr. Camel's Conclusion

This research provides valuable insights into the potential role of stress and pyridostigmine in Gulf War Illness. The study emphasizes the importance of continued research and exploration to understand this mysterious condition and develop effective treatments for those affected.
Date :
  1. Date Completed 2009-09-10
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19433115

DOI: Digital Object Identifier

10.1016/j.bbr.2009.05.002

Related Literature

Article Analysis
・Effects of pyridostigmine
SNS
PICO Info
in preparation
Languages

English

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