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Oseltamivir (tamiflu) is a substrate of peptide transporter 1.

Author: EnomotoShigeki, KanoTakashi, KobayashiShoko, MorimotoKaori, OgiharaTakuo, ShirasakaYoshiyuki, TamaiIkumi, WadaSho, WagatsumaTamae, YabuuchiHikaru

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Oseltamivir, an influenza treatment, is absorbed in the intestines through the peptide transporter 1 (PEPT1).
Paper Details　
Original Abstract of the Article :
Oseltamivir, an ester-type prodrug of the neuraminidase inhibitor [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), has been developed for the treatment of A and B strains of the influenza virus but has neuropsychiatric and other side effects. In t...See full text at original site
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引用元：
https://doi.org/10.1124/dmd.109.026922

データ提供：米国国立医学図書館（NLM）

Oseltamivir: A Journey Through the Body's Transport System

This research delves into the transport mechanisms of oseltamivir, a medication used to treat influenza A and B. The study investigates the role of peptide transporter 1 (PEPT1) in the absorption and distribution of oseltamivir in the body. By understanding these transport processes, researchers can gain insights into the drug's efficacy and potential side effects.

The Road Less Traveled: Uncovering the Secrets of Oseltamivir Transport

The research reveals that oseltamivir is indeed a substrate of PEPT1, a crucial transporter protein in the intestinal tract. This finding has important implications for drug absorption and distribution, impacting the drug's effectiveness and potential side effects. Furthermore, the study highlights the influence of factors such as fasting and the presence of certain food components on oseltamivir's transport, emphasizing the need for careful consideration of these factors in treatment strategies.

Taking the Right Path: Optimizing Oseltamivir Treatment

Understanding how oseltamivir is transported within the body provides valuable insights for optimizing its therapeutic effects. By considering factors such as fasting and the presence of certain food components, healthcare professionals can better tailor treatment plans for individuals, ensuring they get the most out of this important medication. It's like navigating a vast desert – understanding the lay of the land allows us to choose the most efficient and effective route.

Dr.Camel's Conclusion

This research illuminates the intricate transport mechanisms of oseltamivir, highlighting the crucial role of PEPT1 in its absorption and distribution. By unraveling these processes, we gain a deeper understanding of the drug's effectiveness and can develop strategies to optimize treatment outcomes. This knowledge, like a well-traveled desert route, helps us navigate the complex landscape of drug therapy, ensuring a smoother and more successful journey.

Date :
  1. Date Completed 2009-10-19
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

19439487

DOI: Digital Object Identifier

10.1124/dmd.109.026922

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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