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Dose-dependent acute effects of recombinant human TSH (rhTSH) on thyroid size and function: comparison of 0.1, 0.3 and 0.9 mg of rhTSH.

Author: BonnemaSteen J, FastSøren, HegedüsLaszlo, NielsenViveque E

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Recombinant human TSH (rhTSH) is used to augment the effect of radioiodine therapy for nontoxic multinodular goitre. rhTSH-induced thyroid swelling and hyperthyroidism is rapid and dose dependent. Doses of 0.1 mg or less of rhTSH may not be associated with clinically significant adverse effects.
Paper Details　
Original Abstract of the Article :
CONTEXT: Recombinant human TSH (rhTSH) is used to augment the effect of radioiodine therapy for nontoxic multinodular goitre. Reports of acute thyroid swelling and hyperthyroidism warrant safety studies evaluating whether these side-effects are dose dependent. OBJECTIVE: To determine the effects on...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2265.2009.03650.x

データ提供：米国国立医学図書館（NLM）

Recombinant Human TSH (rhTSH): Navigating the Desert of Thyroid Function

Recombinant human TSH (rhTSH) is a valuable tool in the treatment of thyroid disorders, particularly for nontoxic multinodular goitre. This study investigates the dose-dependent effects of rhTSH on thyroid size and function. The researchers aimed to determine the optimal dosage and identify any potential side effects.

Dose-Dependent Effects: Finding the Right Oasis

The study found that rhTSH-induced thyroid swelling and hyperthyroidism were rapid and dose-dependent. This is like a desert oasis that grows larger with more water. It's essential to find the optimal dose, just like finding the right oasis for your needs.

Balancing Benefits and Risks

The researchers concluded that lower doses of rhTSH (0.1 mg or less) were unlikely to cause significant adverse effects in healthy individuals. It's like navigating the desert with a well-stocked caravan, carefully managing resources to avoid problems. This study provides valuable information for clinicians to balance the benefits and risks of rhTSH therapy.

Dr.Camel's Conclusion

This study provides important insights into the dose-dependent effects of rhTSH, highlighting the need for careful dosage adjustments to optimize treatment outcomes. It's like navigating a desert, understanding the terrain and water sources to ensure a safe and successful journey. Further research will continue to refine our understanding of rhTSH and its applications in treating thyroid disorders.

Date :
  1. Date Completed 2010-07-01
  2. Date Revised 2021-01-15
Further Info :

Pubmed ID

19508679

DOI: Digital Object Identifier

10.1111/j.1365-2265.2009.03650.x

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PICO Info
in preparation
Languages

English

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