Paper Details

  1. Home
  2. Paper Details

A study of 3-substituted benzylidene-1,3-dihydro-indoline derivatives as antimicrobial and antiviral agents.

Author: OlgenSüreyya, OzkanSemiha

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the in vitro antibacterial and antifungal activity of 3-substituted benzylidene-1,3-dihydro-indoline derivatives against various Gram-negative and Gram-positive bacteria, as well as Candida species. The most active compound, 10, showed notable inhibition against Bacillus subtilis, Staphylococcus aureus, and Candida krusei. The study also assesses the replication inhibition of these derivatives against the HepAD38 cell line.
Paper Details　
Original Abstract of the Article :
3-Substituted benzylidene-1,3-dihydro-indoline derivatives were tested for their in vitro antibacterial activity against the Gram-negative bacteria Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, and the Gram-positive bacteria Bacillus subtilis, Staphylococcus aureus, and for their ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1515/znc-2009-3-401

データ提供：米国国立医学図書館（NLM）

New Hope for Antimicrobial and Antiviral Therapies: Benzylidene-1,3-dihydro-indoline Derivatives

This research explores the potential of a new class of compounds, 3-substituted benzylidene-1,3-dihydro-indoline derivatives, as antimicrobial and antiviral agents. The study investigated their in vitro activity against various bacterial and fungal strains, as well as their effect on the replication of a hepatitis B virus (HBV) cell line. The researchers found that several compounds exhibited promising antimicrobial activity, particularly against Bacillus subtilis, Staphylococcus aureus, and Candida krusei. One compound, compound 13, also demonstrated activity against HBV. These findings hold potential for developing new therapeutic agents to combat infections and viral diseases.

Promising Compounds for Antimicrobial and Antiviral Therapies

The study's results provide encouraging evidence for the potential of 3-substituted benzylidene-1,3-dihydro-indoline derivatives as novel therapeutic agents. Further research is warranted to explore the efficacy and safety of these compounds in vivo and to optimize their clinical applications.

A New Oasis in the Desert of Infectious Diseases

Think of the desert as a vast landscape where infectious diseases can thrive. This study explores the potential of new compounds, like oases in the desert, to combat these threats. The research holds promise for developing new treatments against various infections and viral diseases, offering hope for better health and well-being.

Dr.Camel's Conclusion

This research highlights the ongoing search for new and effective therapies to combat infectious diseases. The promising results obtained with 3-substituted benzylidene-1,3-dihydro-indoline derivatives provide a glimmer of hope in the battle against bacterial and fungal infections. The study's findings warrant further investigation to translate these promising preclinical results into clinical applications.

Date :
  1. Date Completed 2009-07-28
  2. Date Revised 2019-10-21
Further Info :

Pubmed ID

19526705

DOI: Digital Object Identifier

10.1515/znc-2009-3-401

Related Literature

Article Analysis
・Effects of delavirdine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.