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Neuroprotective effects of probenecid in a transgenic animal model of Huntington's disease.

Author: KlivenyiPeter, VamosEniko, VecseiLaszlo, VorosKrisztina, ZadoriDenes

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Probenecid, a drug used to treat gout, was found to improve survival and reduce neuronal loss in a mouse model of Huntington's disease (HD). This suggests that probenecid may have neuroprotective effects and could potentially be used to treat HD.
Paper Details　
Original Abstract of the Article :
Huntington's disease (HD) is an autosomal dominantly inherited disorder, caused by an expanded polyglutamine region of a protein called huntingtin. The excitotoxicity, oxidative damage and altered membrane transport may have an important role in the pathogenesis of HD. Probenecid is a non-selective ...See full text at original site
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引用元：
https://doi.org/10.1007/s00702-009-0253-6

データ提供：米国国立医学図書館（NLM）

Probenecid: A Potential Shield for Huntington's Disease

[Huntington's disease (HD)] is a debilitating [neurodegenerative disorder] that impacts both physical and cognitive functions. This study investigates the potential neuroprotective effects of [probenecid], a drug commonly used for [gout] treatment, in a [transgenic animal model] of HD. The authors explored the impact of probenecid on [survival], [behavior], and [immunohistochemical changes] in the N171-82Q transgenic mouse model of HD.

Probenecid: A Promising Candidate for HD Treatment

The study's findings suggest that probenecid could potentially mitigate the progression of HD. The researchers observed a significant improvement in [survival duration] and [motor activity] in the probenecid-treated group compared to controls. Additionally, probenecid treatment resulted in a notable reduction in [neuronal loss] and [neuronal intranuclear aggregates].

Hope on the Horizon for Huntington's Disease

This research offers a glimmer of hope for individuals affected by HD. The potential neuroprotective effects of probenecid provide a new avenue for exploring therapeutic interventions for this devastating disease. It's like a camel discovering a hidden oasis in the desert, providing much-needed respite and hope.

Dr.Camel's Conclusion

Huntington's disease can be a relentless adversary, but this study shows that we may have a potential ally in probenecid. The findings suggest that this drug could play a significant role in combating the progression of HD, offering a beacon of hope for those affected by this devastating disease.

Date :
  1. Date Completed 2009-09-30
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19551467

DOI: Digital Object Identifier

10.1007/s00702-009-0253-6

Related Literature

Article Analysis
・Effects of probenecid
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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