Effects of aluminum hydroxide on the parathyroid-vitamin D axis of postmenopausal women.

Author: CheemaM, HollowayL, MarcusR, PackerE, VillaM L

Paper Details 
Original Abstract of the Article :
In previous studies we proposed that estrogen increases circulating calcitriol in postmenopausal women by reducing plasma phosphorus concentrations. For this model to be plausible, a reduction in plasma phosphorus must be itself be sufficient to increase circulating calcitriol in elderly women. To a...See full text at original site
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引用元:
https://doi.org/10.1210/jcem-73-6-1256

データ提供:米国国立医学図書館(NLM)

Exploring the Impact of Aluminum Hydroxide on Phosphorus Levels and Vitamin D Metabolism in Postmenopausal Women

The [postmenopausal period] is often characterized by changes in [bone metabolism] and [calcium homeostasis]. This study investigates the impact of [aluminum hydroxide] on these processes in postmenopausal women. The researchers employed a [controlled trial] design, administering [aluminum hydroxide] to a group of postmenopausal women while maintaining a controlled diet. The study revealed that [aluminum hydroxide] significantly lowered [plasma phosphorus concentrations], which in turn led to a significant increase in [circulating calcitriol levels]. This finding provides evidence for the role of [phosphorus restriction] in regulating [vitamin D metabolism] in postmenopausal women. One notable observation is the lack of significant changes in [parathyroid hormone] levels, suggesting that the observed effects are primarily mediated through [intestinal phosphorus absorption] rather than [parathyroid gland function].

Unraveling the Relationship Between Phosphorus and Vitamin D

This study sheds light on the complex interplay between [phosphorus, vitamin D, and bone health] in postmenopausal women. The findings suggest that [aluminum hydroxide], by reducing [intestinal phosphorus absorption], can effectively increase [calcitriol levels]. This knowledge can potentially inform strategies for [managing bone health] in postmenopausal women.

The Importance of Dietary Management and Further Research

The study's findings emphasize the crucial role of [dietary phosphorus intake] in [vitamin D metabolism] and [bone health] in postmenopausal women. While [aluminum hydroxide] can be an effective tool to modulate [phosphorus levels], further research is needed to determine the long-term effects of this approach. It's also important to note that individuals should consult with a qualified healthcare professional before making any significant changes to their diet or medication regimen.

Dr. Camel's Conclusion

This research, like a shimmering oasis in the vast desert of knowledge, provides valuable insights into the intricate relationship between phosphorus, vitamin D, and bone health in postmenopausal women. The findings suggest that modulating phosphorus levels through dietary or pharmacological interventions may play a significant role in maintaining bone health. However, as with any scientific endeavor, further research is needed to fully understand the implications and refine our approach. Remember, a healthy lifestyle, including proper nutrition and regular exercise, is crucial for maintaining overall well-being throughout life.

Date :
  1. Date Completed 1992-01-02
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1955506

DOI: Digital Object Identifier

10.1210/jcem-73-6-1256

Related Literature

SNS
PICO Info
in preparation
Languages

English

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