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Impaired bioavailability of interferon beta-1a when administered intramuscularly by needle-free injection.

Author: AlamJ J, CharenkavanichS, DiBiaseM, JonesW, KnoxS J, RoggeM C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This Phase I study compared the pharmacokinetic and pharmacodynamic responses of intramuscular (IM) needle-free jet injection and needle-based injection of interferon beta-1a in 12 healthy subjects. Needle-free injection resulted in a 41.1% relative bioavailability compared to standard needle injection. While injection site reactions were more frequent with needle-free injection, systemic side effects were less frequent.
Paper Details　
Original Abstract of the Article :
Intramuscular (IM) or subcutaneous (SC) drug administration of small molecules and protein has been demonstrated by use of needle-free jet injection methods. One device that achieves needle-free parenteral administration, BIOJECTOR, is commercially available and was evaluated for IM delivery of inte...See full text at original site
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引用元：
https://doi.org/10.3109/10717549809065758

データ提供：米国国立医学図書館（NLM）

Impaired Bioavailability of Interferon Beta-1a by Needle-Free Injection

This research explores the potential of [needle-free jet injection] for delivering [interferon beta-1a (IFN beta-1a)], a protein medication used to treat multiple sclerosis. The authors conducted a Phase I clinical trial comparing the bioavailability of IFN beta-1a administered via [standard needle injection] and [needle-free jet injection]. Their findings, like a careful examination of a desert oasis, reveal the limitations of needle-free injection for delivering this specific medication.

The Challenge of Needle-Free Delivery

The study's results demonstrate that [needle-free jet injection of IFN beta-1a results in significantly lower bioavailability] compared to standard needle injection. This finding highlights the importance of [considering the unique properties of medications] when exploring alternative delivery methods.

Navigating the Desert of Drug Delivery

The study underscores the need for [further research and development] to optimize needle-free delivery methods for medications like IFN beta-1a. It reminds us that the journey towards more convenient and accessible drug delivery requires careful exploration and innovation.

Dr.Camel's Conclusion

This research unveils the challenges of using needle-free jet injection for delivering interferon beta-1a. It emphasizes the importance of carefully considering the specific properties of medications when exploring alternative delivery methods. Remember, even in the vast desert of medical advancements, finding the right path for drug delivery requires a thorough understanding of both medication and technology.
Date :
  1. Date Completed 2010-06-25
  2. Date Revised 2009-07-02
Further Info :

Pubmed ID

19569995

DOI: Digital Object Identifier

10.3109/10717549809065758

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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