Paper Details

  1. Home
  2. Paper Details

Effects of estramustine on DNA and cell membrane in malignant glioma cells.

Author: GrankvistK, GustavssonH, HenrikssonR, von SchoultzE

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Estramustine phosphate (EMP) induced DNA strand breaks and reduced cell membrane permeability in malignant glioma cells.
Paper Details　
Original Abstract of the Article :
Estramustine phosphate (EMP), a complex between estradiol-17 beta and nor-nitrogen mustard, commonly used in treatment of prostatic cancer, also exerts marked antiproliferative effects on cultured human malignant glioma cells. The mechanism of action is unknown but has previously been considered to ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.3109/02841869109092446

データ提供：米国国立医学図書館（NLM）

Estramustine: A Double-Edged Sword in the Fight Against Glioma

Malignant glioma, a type of brain tumor, presents a daunting challenge for medical professionals. This study investigates the effects of estramustine phosphate (EMP), a drug typically used for prostate cancer, on malignant glioma cells. The researchers explored the mechanisms of action of EMP, aiming to understand its potential as a therapeutic agent for glioma.

EMP: A Potential New Weapon Against Glioma

The study found that EMP induced DNA strand breaks and reduced membrane permeability in malignant glioma cells. These findings suggest that EMP may possess anticancer activity against glioma, but further research is needed to confirm its efficacy and safety in human patients.

Navigating the Uncertainties in Cancer Treatment

This research highlights the need for continued exploration of new therapeutic approaches for brain tumors. EMP, a potential new weapon in the desert of glioma treatment, encourages further investigation into its use in this challenging disease.

Dr.Camel's Conclusion

This study is a reminder that the desert of cancer research holds many hidden treasures waiting to be uncovered. EMP, a potential new weapon in the fight against glioma, inspires us to keep searching for innovative solutions to conquer this formidable foe. It is through ongoing research and exploration that we can discover new paths to healing and improved health outcomes.

Date :
  1. Date Completed 1992-01-09
  2. Date Revised 2019-09-03
Further Info :

Pubmed ID

1958392

DOI: Digital Object Identifier

10.3109/02841869109092446

Related Literature

Article Analysis
・Effects of estramustine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.