Once daily baclofen sustained release or gastro-retentive system are acceptable alternatives to thrice daily baclofen immediate release at same daily dosage in patients.

Author: BhattacharyaAmal K, BhowmikShravanti S, JoshiNishith H, KulkarniRahul V, LakhaniJ D, SampatNitin G, SaseNathaniel, VoraPragnesh B

Paper Details 
Original Abstract of the Article :
Baclofen, a GABA-agonist, is currently available as an immediate release (IR) formulation for relieving neurogenic spasticity in a variety of disorders. Baclofen IR requires to be administered three times a day which inadvertently increases the chances of medication noncompliance among patients and ...See full text at original site
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引用元:
https://doi.org/10.4103/0028-3886.53284

データ提供:米国国立医学図書館(NLM)

Baclofen: Finding the Right Dose and Delivery

The field of [neurology] is always seeking to optimize treatment for [neurogenic spasticity]. This study explores the use of different [baclofen] formulations for managing spasticity. Researchers compared [once daily baclofen sustained release, gastro-retentive system, and thrice daily baclofen immediate release] in patients with spasticity. They found that [once daily baclofen sustained release and gastro-retentive system] were acceptable alternatives to thrice daily immediate release baclofen at the same daily dose. The study highlighted [the potential for improved patient adherence and reduced side effects] with these alternative formulations.

Improving Baclofen Therapy for Spasticity

This research provides a practical approach to [optimizing baclofen therapy] for patients with spasticity. The study's findings demonstrate [the effectiveness of sustained release and gastro-retentive baclofen formulations] in achieving therapeutic outcomes.

Navigating the Desert of Spasticity Treatment

Managing spasticity can feel like navigating a desert with limited resources. This study offers a beacon of hope for patients, providing [practical alternatives to traditional baclofen therapy] that could enhance their treatment experience.

Dr. Camel's Conclusion

This study offers a refreshing perspective on baclofen therapy for spasticity. The researchers have discovered a new oasis for patients, providing alternative formulations that could improve adherence and minimize side effects.

Date :
  1. Date Completed 2009-10-29
  2. Date Revised 2014-07-30
Further Info :

Pubmed ID

19587470

DOI: Digital Object Identifier

10.4103/0028-3886.53284

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Languages

English

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