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[The noninvasive assessment of the effects of penbutolol on liver hemodynamics in cirrhotic patients using angioscintigraphy. A randomized controlled double-blind study].

Author: BestettiA, BrunoS, ChiesaA, GaglianoG, GrugniM C, OpocherE, RossiS, SantambrogioR, VignatiL, ZattaG

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Penbutolol, a new beta-blocker, reduced portal perfusion index by 29% in patients with cirrhosis and esophageal varices, without significantly affecting total hepatic blood flow or systemic hemodynamics.
Paper Details　
Original Abstract of the Article :
This randomized double-blind controlled study analyzed the hemodynamic effects of penbutolol, a new levo-rotatory betablocker, using radionuclide angiography. Twenty cirrhotics with esophageal varices were randomized: 10 received 40 mg/day of penbutolol orally and the others a placebo. Angioscintigr...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1962892

データ提供：米国国立医学図書館（NLM）

Assessing Liver Hemodynamics in Cirrhotic Patients

Liver cirrhosis, a serious condition affecting the liver, can lead to complications such as [portal hypertension] and [esophageal varices]. This study investigates the hemodynamic effects of penbutolol, a beta-blocker medication, in patients with cirrhosis, using a non-invasive technique called [angioscintigraphy].

Penbutolol's Impact on Liver Hemodynamics

The study reveals that penbutolol significantly reduced portal perfusion index and increased hepatic artery index in patients with cirrhosis, suggesting a potential therapeutic benefit in managing hemodynamic imbalances associated with the condition.

Angioscintigraphy: A Valuable Tool for Liver Assessment

The study underscores the importance of angioscintigraphy as a safe, accurate, and reproducible method for assessing liver hemodynamics in patients with cirrhosis. This technique offers a valuable tool for monitoring treatment response and guiding clinical decision-making.

Dr.Camel's Conclusion

This study delves deep into the intricate world of liver hemodynamics, revealing the potential of penbutolol in managing this challenging condition. It emphasizes the importance of non-invasive techniques like angioscintigraphy, providing a powerful tool for navigating the complexities of liver disease.

Date :
  1. Date Completed 1991-03-28
  2. Date Revised 2016-11-23
Further Info :

Pubmed ID

1962892

DOI: Digital Object Identifier

1962892

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PICO Info
in preparation
Languages

Italian

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