[Effects of fluid shear stress time on carbonic anhydrase in rat osteoclasts].

Author: WangWei-qian, ZhangQing-hong, ZhuBao-min

Paper Details 
Original Abstract of the Article :
PURPOSE: To observe the effects of fluid shear stress on carbonic anhydrase II in rat osteoclasts. METHODS: Osteoclasts were subject to fluid shear stress for 0,15,30,60 and 120 minutes respectively, which was 2.9dyne/cm(2). mRNA level of carbonic anhydrase II was detected through real-time fluores...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/19649531

データ提供:米国国立医学図書館(NLM)

The Dynamic Dance of Fluid Shear Stress and Carbonic Anhydrase in Osteoclasts

This study explores the fascinating world of osteoclasts, bone-resorbing cells that are essential for bone remodeling. Imagine osteoclasts as tiny sculptors, carefully chiseling away at bone tissue to maintain its healthy structure! This study investigates how fluid shear stress, a force exerted by flowing fluids, influences the activity of carbonic anhydrase, an enzyme crucial for osteoclast function.

Fluid Shear Stress and Carbonic Anhydrase: A Complex Relationship

The authors employed a [research methodology] to examine the effects of fluid shear stress on carbonic anhydrase II in rat osteoclasts. They found that the expression of carbonic anhydrase II increased with increasing durations of fluid shear stress. This suggests a dynamic relationship between these two factors, with fluid shear stress playing a key role in regulating the activity of carbonic anhydrase.

The Significance of Fluid Shear Stress in Bone Health

Understanding the relationship between fluid shear stress and carbonic anhydrase could lead to new insights into bone health and disease. It's like uncovering a hidden secret in the desert sands! This research suggests that fluid shear stress may play a crucial role in the activity of osteoclasts, potentially influencing the bone remodeling process.

Dr. Camel's Conclusion

This study, like a camel trekking across the desert, brings us closer to understanding the complex mechanisms that govern bone health. The fascinating interplay of fluid shear stress and carbonic anhydrase in osteoclasts reveals a dynamic interplay between physical forces and cellular activity, paving the way for potential therapeutic interventions.
Date :
  1. Date Completed 2015-06-19
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

19649531

DOI: Digital Object Identifier

19649531

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SNS
PICO Info
in preparation
Languages

Chinese

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