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Effects of antidepressants on plasma metabolites of nitric oxide in major depressive disorder: comparison between milnacipran and paroxetine.

Author: HoriHikaru, Ikenouchi-SugitaAtsuko, NakamuraJun, UedaNobuhisa, Umene-NakanoWakako, YoshimuraReiji

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examined plasma NOx levels in patients with major depressive disorder and healthy controls. Depressed patients had significantly lower baseline NOx levels than controls. Treatment with milnacipran, but not paroxetine, significantly increased NOx levels after 4 and 8 weeks.
Paper Details　
Original Abstract of the Article :
Depression is a risk factor for coronary heart disease (CHD). It has been demonstrated that there is a potential role of nitric oxide (NO) in the relationship between depression and CHD risk as well as an effect of antidepressants on NO production. This study included 40 in- or outpatients in our un...See full text at original site
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引用元：
https://doi.org/10.1016/j.pnpbp.2009.07.028

データ提供：米国国立医学図書館（NLM）

Antidepressants and Nitric Oxide Metabolism: A Closer Look

Depression, like a desert mirage, can distort our perception of the world. This study delves into the link between depression and nitric oxide (NO) metabolism, examining the effects of antidepressants on plasma NOx levels in patients with major depressive disorder.

Milnacipran: A Potential Modulator of Nitric Oxide Metabolism

The researchers discovered that milnacipran, a serotonin-norepinephrine reuptake inhibitor, significantly increased plasma NOx levels in depressed patients. This finding is like a desert oasis, providing a potential avenue for improving the treatment of depression.

Understanding Depression and Nitric Oxide

This study contributes to our understanding of the complex interplay between depression and nitric oxide metabolism. It's like uncovering a hidden pathway in the vast desert of mental health, guiding us towards more effective treatments.

Dr.Camel's Conclusion

This research offers intriguing insights into the potential role of nitric oxide in depression and the effects of antidepressants on its metabolism. It's like a desert explorer discovering a new and promising route, leading us towards a better understanding of this complex condition.
Date :
  1. Date Completed 2010-01-25
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

19664676

DOI: Digital Object Identifier

10.1016/j.pnpbp.2009.07.028

Related Literature

Article Analysis
・Effects of milnacipran
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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