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Pathological effects of prostate cancer correlate with neuroendocrine differentiation and PTEN expression after bicalutamide monotherapy.

Author: ChoNam Hoon, ChoiYoung Deuk, HamWon Sik, JuHee Jeong, KimWon Tae, LeeJin Sun

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study analyzed the expression of PTEN, HER2, and neuroendocrine differentiation after bicalutamide monotherapy in patients with advanced prostate cancer. Understanding these molecular changes is important for evaluating the efficacy of second-line therapies.
Paper Details　
Original Abstract of the Article :
Androgen deprivation therapy is the primary treatment for advanced prostate cancer but many patients eventually experience progression to hormone refractory status. Understanding the molecular changes after androgen deprivation therapy would help evaluate the efficacy or failure of second line thera...See full text at original site
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引用元：
https://doi.org/10.1016/j.juro.2009.06.025

データ提供：米国国立医学図書館（NLM）

The Impact of Bicalutamide Monotherapy on Prostate Cancer Progression: A Molecular Perspective

This research investigates the molecular changes that occur in prostate cancer after treatment with bicalutamide monotherapy, a common approach for managing advanced prostate cancer. It's like delving into the hidden cellular landscape of prostate cancer, seeking to understand the mechanisms of resistance and progression. The study examines the expression of key molecular markers, including PTEN, HER-2, and neuroendocrine differentiation, after bicalutamide treatment.

Understanding Prostate Cancer Progression: A Crucial Step in Treatment

The study provides insights into the molecular mechanisms underlying prostate cancer progression after bicalutamide monotherapy. It's like uncovering a map that reveals the changing terrain of the disease, allowing for more informed treatment strategies. The findings suggest that the expression of PTEN and neuroendocrine differentiation are important factors to consider in predicting prostate cancer progression.

Navigating the Desert of Prostate Cancer: Developing More Effective Therapies

This research highlights the need for a deeper understanding of the molecular changes that occur in prostate cancer after treatment. It's like gaining a new perspective on the vast desert of prostate cancer research, one that reveals the hidden mechanisms driving disease progression. The study underscores the importance of developing more effective therapies that target these molecular pathways and prevent resistance to treatment.

Dr.Camel's Conclusion

This study offers valuable insights into the molecular changes that drive prostate cancer progression, providing a foundation for developing more effective treatments. It's like uncovering a hidden oasis of knowledge in the vast desert of prostate cancer research, one that could lead to new and improved therapies for patients.
Date :
  1. Date Completed 2009-10-02
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

19683286

DOI: Digital Object Identifier

10.1016/j.juro.2009.06.025

Related Literature

Article Analysis
・Effects of bicalutamide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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