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The role of topical vitamin D modulators in psoriasis therapy.

Author: TanghettiEmil A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Psoriasis affects over 5 million adults in the U.S., impacting quality of life and treatment costs. Topical corticosteroids, the most common treatment, can have side effects with long-term use. Topical vitamin D agents, such as calcipotriene, are newer options that inhibit keratinocyte proliferation, normalize differentiation, and modulate immune cells with minimal effect on serum calcium hemostasis. Calcipotriene is as effective as low-to-medium potency corticosteroids but can cause skin irritation. Calcitriol ointment, the only vitamin D3 ointment available in the U.S., has a lower rate of side effects.
Paper Details　
Original Abstract of the Article :
Psoriasis affects more than 5 million adults in the United States (U.S.), causing significant impairments in quality of life and incurring substantial costs in treatment. The disease is characterized by hyperproliferation and abnormal differentiation of epidermal keratinocytes resulting from a disor...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/19702030

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Psoriasis: Exploring Topical Vitamin D Therapy

Psoriasis, a chronic skin condition, can feel like navigating a vast and unforgiving desert, with its persistent scaling and irritation. This study explores the potential of topical vitamin D modulators as a therapeutic option for psoriasis. The researchers delve into the mechanisms of action of these agents, highlighting their ability to inhibit keratinocyte proliferation, normalize differentiation, and modulate immune activity. The study focuses on calcipotriene, a widely used topical vitamin D agent, and examines its effectiveness and side effects.

Seeking Relief in the Desert: Exploring Topical Vitamin D Therapy

The study found that topical vitamin D agents, particularly calcipotriene, can be effective in treating psoriasis. The findings suggest that these agents offer a promising alternative to traditional therapies, such as corticosteroids, with a lower risk of adverse effects.

Navigating the Desert of Psoriasis: Finding the Right Path

This research sheds light on the potential of topical vitamin D therapy for psoriasis. The study emphasizes the importance of consulting with a healthcare professional to determine the most appropriate treatment options for individual patients. By working together, we can find the right path to relief in the desert of psoriasis.

Dr.Camel's Conclusion

This research provides a valuable resource for navigating the desert of psoriasis. The findings highlight the potential of topical vitamin D agents as a promising avenue for treatment, offering hope for those seeking relief from this challenging condition.

Date :
  1. Date Completed 2009-09-14
  2. Date Revised 2009-08-25
Further Info :

Pubmed ID

19702030

DOI: Digital Object Identifier

19702030

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・Side Effects of calcitriol topical
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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