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Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections.

Author: BuzonRichard A, ChupakLou, DoughertyThomas J, FalconeMichael J, FarleyKathleen A, FineganSteven M, FlanaganMark E, GirardDennis, GranskogKarl, HagenAnne E, HardinkJoel R, HubandMichael D, KamickerBarbara J, KanekoTakushi, KnickerbockerMichael J, LiBryan, LirasJennifer L, MageeThomas V, MarraAndrea, MedinaIvy, NguyenThuy-Trinh, NoeMark C, O'DonnellJohn P, ObachR Scott, PenzienJoseph B, ReillyUsa Datta, RippSharon L, SchaferJohn R, ShenYue, StoneGregory G, StrelevitzTimothy J, SunJianmin, Tait-KamradtAmelia, VazAlfin D N, WhippleDavid A, WidlickaDaniel W, WishkaDonn G, WolkowskiJoanna P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Azetidinyl ketolides are a novel series of macrolide antibiotics that mitigate hepatotoxicity while maintaining potency and efficacy, potentially addressing the safety concerns associated with telithromycin.
Paper Details　
Original Abstract of the Article :
Respiratory tract bacterial strains are becoming increasingly resistant to currently marketed macrolide antibiotics. The current alternative telithromycin (1) from the newer ketolide class of macrolides addresses resistance but is hampered by serious safety concerns, hepatotoxicity in particular. We...See full text at original site
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引用元：
https://doi.org/10.1021/jm900729s

データ提供：米国国立医学図書館（NLM）

Azetidinyl Ketolides: A New Oasis in the Desert of Antibiotic Resistance

The emergence of [multidrug resistant bacteria] is a growing threat, creating a vast desert of untreatable infections. This study, like a camel seeking a path through a challenging landscape, explores the development of [azetidinyl ketolides] as a new class of [antibiotics] for the treatment of [susceptible and multidrug resistant community-acquired respiratory tract infections]. The researchers designed these novel compounds to [address the limitations] of [current macrolide antibiotics] while mitigating potential [safety concerns] associated with existing ketolides.

A New Weapon in the Arsenal: Azetidinyl Ketolides Offer Promise

This research offers a potential solution to the growing problem of [antibiotic resistance], presenting a new class of antibiotics with the potential to combat resistant infections.

The Desert of Antibiotic Resistance: A Call for Continued Innovation

The desert of antibiotic resistance is a challenging terrain that demands continuous innovation. By investing in [research and development] of new antibiotics and promoting [responsible antibiotic use], we can help preserve the effectiveness of these crucial medications for future generations.

Dr.Camel's Conclusion

The development of azetidinyl ketolides represents a promising advancement in the fight against antibiotic resistance. These novel compounds offer a potential oasis of hope in the desert of untreatable infections, highlighting the importance of ongoing research and development in this crucial area of medicine.

Date :
  1. Date Completed 2009-12-31
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

19775168

DOI: Digital Object Identifier

10.1021/jm900729s

Related Literature

Article Analysis
・Side Effects of telithromycin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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