The effects of excipients for topical preparations on the human skin permeability of terpinen-4-ol contained in Tea tree oil: infrared spectroscopic investigations.

Author: CasiraghiAntonella, CilurzoFrancesco, GambaroVeniero, MinghettiPaola, MontanariLuisa, SelminFrancesca

Paper Details 
Original Abstract of the Article :
This work aimed to evaluate the effect induced by excipients conventionally used for topical dosage forms, namely isopropyl myristate (IPM) or oleic acid (OA) or polyethylene glycol 400 (PEG400) or Transcutol (TR), on the human skin permeability of terpinen-4-ol (T4OL) contained in the pure Tea tree...See full text at original site
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引用元:
https://doi.org/10.3109/10837450903338387

データ提供:米国国立医学図書館(NLM)

Tea Tree Oil: A Skin-Deep Exploration

The study focuses on the intriguing world of tea tree oil, a natural remedy known for its potential skin benefits. The researchers investigated the impact of different excipients, substances used to enhance the delivery of active ingredients in topical preparations, on the human skin permeability of terpinen-4-ol, a key component of tea tree oil. They discovered that oleic acid, a fatty acid, significantly enhanced the absorption of terpinen-4-ol into the skin, suggesting its potential to improve the effectiveness of tea tree oil-based topical products. This research sheds light on the importance of excipient selection in maximizing the efficacy of topical treatments.

Oleic Acid - A Key to Unlock Tea Tree Oil's Potential

The study highlights the crucial role of oleic acid in enhancing the skin permeability of terpinen-4-ol. Imagine a camel caravan traveling through a desert - a well-chosen path can make the journey smoother and more efficient. Similarly, the appropriate excipient, like oleic acid, can guide the active ingredient, terpinen-4-ol, through the skin's barriers, leading to better absorption and a more effective outcome.

Tea Tree Oil - A Natural Remedy with a Twist

This study reminds us that even natural remedies like tea tree oil can be influenced by the way they are formulated. The choice of excipients plays a significant role in determining the effectiveness of topical treatments. Just like a camel needs the right equipment for a successful journey, a topical remedy needs the right excipients to deliver its full potential.

Dr.Camel's Conclusion

This research underlines the importance of excipients in maximizing the effectiveness of topical treatments, particularly for natural remedies like tea tree oil.

Date :
  1. Date Completed 2010-12-10
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

19842911

DOI: Digital Object Identifier

10.3109/10837450903338387

Related Literature

SNS
PICO Info
in preparation
Languages

English

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