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Cladribine inhibits a diltiazem-induced increase in red blood cell purine nucleotide concentrations in a zebrafish model.
Author: BermanJason N, KleinLauren C, YeungPollen K
Original Abstract of the Article :
Minimizing drug interactions is paramount to improving the efficacy and tolerability of cancer therapy. The zebrafish represents an innovative cancer model due to highly conserved genetics and inherent capacity for high-throughput chemical screening. This pilot study extends the utility of the zebra...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.3109/13547500903131698
データ提供:米国国立医学図書館(NLM)
Cladribine and Diltiazem: A Balancing Act in the Desert of Drug Interactions
Drug interactions can be a real challenge, like trying to navigate a sandstorm without a compass. This research investigates the interaction between cladribine, a nucleoside analogue used in cancer therapy, and diltiazem, a calcium channel blocker used for heart conditions. The study used zebrafish as a model to examine the effect of cladribine and diltiazem on red blood cell purine nucleotide concentrations. The results showed that diltiazem increased red blood cell ATP concentrations, but this effect was inhibited by co-injection of cladribine. This interaction is like a delicate balance in the desert ecosystem – a change in one factor can ripple through the entire system.
Navigating the Sandstorm: Understanding Drug Interactions
This study highlights the importance of considering drug interactions, especially when using multiple medications. It's like knowing the terrain and understanding the potential hazards before embarking on a journey across the desert. Always consult with your doctor to ensure safe and effective medication use.
Staying Safe in the Desert: Avoiding Unforeseen Interactions
This research underscores the importance of understanding drug interactions. It's like having a reliable guide who knows the desert's secrets and can help us navigate the potential hazards. Always talk to your doctor about any medications you are taking, especially when starting new treatments.
Dr.Camel's Conclusion
This research highlights the potential for drug interactions between cladribine and diltiazem. It's a reminder that the desert of drug interactions is complex and requires careful navigation. Always consult with a healthcare professional to ensure safe and effective medication use.
Date :
- Date Completed 2010-03-19
- Date Revised 2022-02-24
Further Info :
Related Literature
English
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