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Drugs and autoimmunity--a contemporary review and mechanistic approach.

Author: ChangChristopher, GershwinM Eric

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Drug-induced autoimmunity can be caused by various mechanisms, including altered gene transcription, cytokine imbalance, and tolerance breakdown. Although many drugs can induce autoantibodies, only a few are strongly linked to autoimmune diseases.
Paper Details　
Original Abstract of the Article :
Drug-induced autoimmunity is an idiosyncratic, non-IgE immune related drug reaction. Interestingly, although many drugs have been reported to induce autoantibodies, only a few have a definitive association with drug-induced autoimmune disease. The prototype disease is drug-induced lupus and the typi...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.jaut.2009.11.012

データ提供：米国国立医学図書館（NLM）

Drugs and Autoimmunity: A Complex Relationship

The world of [autoimmunity] is complex, involving the body's immune system mistakenly attacking its own tissues. This study examines the intriguing relationship between [drugs] and [autoimmunity], focusing on [drug-induced autoimmunity], a rare but important side effect of certain medications. The study reviews the mechanisms by which drugs can induce [autoantibodies] and trigger autoimmune responses. It highlights the importance of understanding these mechanisms to develop safer medications and manage potential autoimmune side effects.

Unveiling the Hidden Connections Between Drugs and Autoimmunity

This study provides valuable insights into the complex relationship between [drugs] and [autoimmunity]. It sheds light on the diverse mechanisms by which drugs can trigger autoimmune responses, emphasizing the need for ongoing research to understand these interactions and develop safer medications. This knowledge is crucial for preventing and managing drug-induced autoimmune diseases.

Navigating the World of Medications with Awareness

Just as a camel needs to be wary of potential dangers in the desert, we must approach [medication use] with awareness and understanding. This study reminds us that even commonly used drugs can have unexpected side effects. Being informed about potential risks and working closely with healthcare professionals is essential for managing medications safely and effectively.

Dr.Camel's Conclusion

This study delves into the fascinating and complex world of [drug-induced autoimmunity]. It reminds us that even seemingly innocuous medications can trigger autoimmune responses, highlighting the importance of understanding the mechanisms involved. Just as a camel navigates the desert with caution, we must approach medication use with awareness and vigilance to protect our health and well-being.

Date :
  1. Date Completed 2010-09-07
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

20015613

DOI: Digital Object Identifier

10.1016/j.jaut.2009.11.012

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English

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