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Azithromycin reduces ocular infection during congenital transmission of toxoplasmosis in the Calomys callosus model.

Author: BernardesEmerson S, FerroEloisa A V, FirminotMarise L, LopesCarla D, PenaJanethe D O, Roque-BarreiraMaria C, SilvaNeide M, SousaRichard A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the efficacy of azithromycin in reducing congenital transmission of Toxoplasma gondii in pregnant mice. The results showed that azithromycin, in combination with pyrimethamine and sulfadiazine, reduced T. gondii infection in the brains of mothers and prevented parasite detection in the eyes of fetuses. Azithromycin may represent an alternative treatment for toxoplasmosis during pregnancy, but further research is needed to confirm its effectiveness.
Paper Details　
Original Abstract of the Article :
Toxoplasma gondii is a widely distributed obligatory intracellular parasite that causes severe disease to the fetus when transmitted during pregnancy. Drugs used to avoid congenital transmission have shown side effects, and their efficacy is controversial. The most widely used treatment for acute to...See full text at original site
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引用元：
https://doi.org/10.1645/GE-1765.1

データ提供：米国国立医学図書館（NLM）

Azithromycin: A Potential Oasis in the Desert of Congenital Toxoplasmosis

Congenital toxoplasmosis, a parasitic infection transmitted from mother to fetus during pregnancy, can have devastating consequences for the developing child. This study investigates the potential of azithromycin, an antibiotic, to reduce ocular infection during congenital transmission of toxoplasmosis in a rodent model. The researchers, seeking to minimize the risk of ocular complications, explored the effectiveness of azithromycin in combination with standard therapy for toxoplasmosis.

Finding the Oasis of Protection: Minimizing Ocular Infection in Congenital Toxoplasmosis

The study provides promising evidence that azithromycin, when combined with standard therapy, can effectively reduce ocular infection in a rodent model of congenital toxoplasmosis. This discovery suggests that azithromycin may offer a potential new avenue for preventing ocular complications associated with congenital toxoplasmosis in humans.

Navigating the Desert of Congenital Toxoplasmosis: Hope for a Healthier Future

This research offers a beacon of hope for preventing ocular complications associated with congenital toxoplasmosis. While further research is needed to confirm its effectiveness in humans, the findings suggest that azithromycin could potentially play a vital role in minimizing the long-term effects of this parasitic infection, providing a path toward a brighter and healthier future for children.

Dr.Camel's Conclusion

This study offers promising insights into the potential benefits of azithromycin for preventing ocular infection in congenital toxoplasmosis. It's a reminder that with continued research and innovation, we can find new oases of hope in the desert of infectious diseases, providing a path toward healthier futures for children.

Date :
  1. Date Completed 2010-01-05
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

20050006

DOI: Digital Object Identifier

10.1645/GE-1765.1

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Article Analysis
・Side Effects of sulfadiazine
SNS
PICO Info
in preparation
Languages

English

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