Electrophysiological characterization of isolated human atrial myocytes exposed to tegaserod.

Author: CerbaiElisabetta, El MouelhiMohamed, GiuntiGabriele, MugelliAlessadro, PfannkucheHans-Jürgen, SuffrediniSilvia

Paper Details 
Original Abstract of the Article :
Tegaserod (Teg), a 5-hydroxytryptamine type-4 (5-HT(4)) receptor partial agonist, represents a novel treatment for irritable bowel syndrome with constipation and chronic constipation. Cardiovascular safety data from pooled clinical studies showed a signal suggestive of increased occurrence of ischae...See full text at original site
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引用元:
https://doi.org/10.1111/j.1742-7843.2009.00507.x

データ提供:米国国立医学図書館(NLM)

Tegaserod: A Controversial Drug for Irritable Bowel Syndrome

The world of gastrointestinal research is constantly seeking better treatments for conditions like irritable bowel syndrome (IBS). This study focuses on tegaserod (Teg), a drug designed to alleviate constipation. However, Teg's use was suspended due to concerns about its potential effects on the heart. The researchers used human heart cells in their study to investigate whether Teg could trigger potentially dangerous heart rhythm problems.

Tegaserod: A Tale of Two Hearts

The study findings were reassuring. Teg did not significantly affect the normal rhythm of human heart cells, even at high doses. This suggests that Teg's potential to cause heart rhythm problems is unlikely to be a major concern. However, the study did find that Teg could affect a specific type of electrical current in heart cells, but this effect was only observed at very high doses, far beyond what is normally used in treatment.

Protecting Your Heart: A Reminder to Consult Your Doctor

This study underscores the importance of carefully considering the potential risks and benefits of medications. While Teg's potential for heart rhythm problems appears to be minimal, it's crucial to consult with your doctor about any concerns you may have. They can help you weigh the potential benefits and risks of any medication you are considering.

Dr.Camel's Conclusion

Just like a camel navigating a treacherous desert landscape, Teg's path to widespread use has been challenging. This study provides valuable information, reassuring us that Teg's potential to cause heart rhythm problems is unlikely to be a major concern. However, as with any medication, it's essential to consult with your doctor and carefully consider both the potential benefits and risks.

Date :
  1. Date Completed 2010-11-22
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

20050846

DOI: Digital Object Identifier

10.1111/j.1742-7843.2009.00507.x

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