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Human pharmacology and abuse potential of nalmefene.

Author: FudalaP J, HeishmanS J, HenningfieldJ E, JohnsonR E

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Nalmefene did not produce morphine-like effects in six male volunteers with opiate abuse history, demonstrating no abuse potential.
Paper Details　
Original Abstract of the Article :
Nalmefene hydrochloride was administered to six male volunteers with histories of opiate abuse using a double-blind, randomized, Latin square design to determine if it produced typical morphine-like effects. A comparison of physiologic and subject- and observer-reported effects was made between morp...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1038/clpt.1991.32

データ提供：米国国立医学図書館（NLM）

Understanding the Potential for Abuse of Nalmefene

Nalmefene, a medication used to treat opioid dependence, is a valuable tool in the fight against addiction. However, understanding the potential for abuse of this medication is crucial. This research investigates the potential abuse liability of nalmefene, assessing its effects on human volunteers with a history of opioid abuse. The researchers compared the effects of nalmefene to those of morphine, a potent opioid, using a double-blind, randomized design.

Nalmefene: A Low Abuse Potential

The study found that nalmefene did not produce typical morphine-like effects, such as euphoria or increased 'drug liking'. It also did not induce changes in subjective measures of dysphoria or sedation. While nalmefene produced some adverse effects, these were not related to its opioid-like properties.

A Safer and More Effective Approach to Treatment

This research provides valuable information for clinicians and patients regarding the safety and effectiveness of nalmefene. It suggests that nalmefene is a valuable tool in the treatment of opioid dependence with a low potential for abuse. It's like finding a reliable oasis in the desert of addiction, offering a safer and more effective path to recovery.

Dr.Camel's Conclusion

This research provides valuable insights into the safety and potential for abuse of nalmefene. It's like finding a well-protected oasis in the desert of addiction, offering a safe and effective haven for those seeking treatment. This study offers reassurance regarding the low abuse potential of nalmefene, reinforcing its role as a valuable tool in the fight against opioid dependence.

Date :
  1. Date Completed 1991-04-29
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

2007323

DOI: Digital Object Identifier

10.1038/clpt.1991.32

Related Literature

Article Analysis
・Effects of morphine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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