Androgen receptor-dependent activation of endothelial nitric oxide synthase in vascular endothelial cells: role of phosphatidylinositol 3-kinase/akt pathway.

Author: AkishitaMasahiro, EtoMasato, KatoShigeaki, OgawaSumito, OkabeTetsuro, OuchiYasuyoshi, SonBo-Kyung, YuJing

Paper Details 
Original Abstract of the Article :
The mechanisms of testosterone-induced vasodilatation are not fully understood. This study investigated the effect of testosterone on nitric oxide (NO) synthesis and its molecular mechanism using human aortic endothelial cells (HAEC). Testosterone at physiological concentrations (1-100 nm) induced a...See full text at original site
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引用元:
https://doi.org/10.1210/en.2009-1048

データ提供:米国国立医学図書館(NLM)

Testosterone's Role in Vasodilation: A Tale of Two Hormones

This research delves into the fascinating world of [Hormones] and their impact on vascular health. The study focuses on testosterone, a male hormone, and its effects on nitric oxide (NO) synthesis, a crucial process for vasodilation. The researchers, like explorers navigating the intricate network of the human body, sought to understand the mechanisms behind testosterone-induced vasodilation, a process as complex as the shifting sands of a desert. They investigated the role of the androgen receptor (AR), a key player in testosterone signaling, and found that it is crucial for testosterone's ability to activate endothelial NO synthase (eNOS), the enzyme responsible for NO production.

The Power of Testosterone: A Hidden Oasis in the Desert of Vasodilation

The study revealed that testosterone, at physiological concentrations, rapidly stimulates NO production through AR-dependent activation of eNOS. This finding highlights the important role of testosterone in maintaining vascular health and sheds light on potential therapeutic strategies for cardiovascular diseases. Imagine, if you will, a camel discovering a hidden oasis in the desert, bringing relief and sustenance to its journey. This study reveals a similar oasis in the desert of vascular health, highlighting the vital role of testosterone in maintaining blood flow.

The Secret to Vascular Health: A Balance of Hormones

This research emphasizes the importance of understanding the complex interplay of hormones in maintaining vascular health. Further research into the role of testosterone and other hormones in vascular function could lead to new treatments for cardiovascular diseases. Just as a camel needs a balance of water and nourishment to survive the desert, our bodies need a balance of hormones to function properly.

Dr.Camel's Conclusion

This study unveils a hidden oasis in the desert of vascular health, revealing the vital role of testosterone in stimulating nitric oxide production. It's like discovering a secret spring in the vast sands of the human body! This research highlights the importance of understanding the complex interplay of hormones and their impact on our health.

Date :
  1. Date Completed 2010-04-09
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

20194727

DOI: Digital Object Identifier

10.1210/en.2009-1048

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Languages

English

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