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Identification of proteasome gene regulation in a rat model for HIV protease inhibitor-induced hyperlipidemia.
Author: CiurlionisRita, DegoeyDavid A, KempfDale J, KleinLarry L, MarshKennan, RandolphJohn T, SpearBrian, WaringJeffrey F
Original Abstract of the Article :
Patients treated with highly active antiretroviral therapy may develop metabolic side effects such as hyperlipidemia, insulin resistance, lipoatrophy and lactic acidosis. The pathophysiology of these metabolic abnormalities is unknown, although some, e.g., lactic acidosis and lipoatrophy, are more a...See full text at original site
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引用元：
https://doi.org/10.1007/s00204-010-0527-7
データ提供：米国国立医学図書館（NLM）
Proteasome Gene Regulation and HIV Protease Inhibitor-Induced Hyperlipidemia
The development of [highly active antiretroviral therapy (HAART)] has transformed [HIV] treatment, but it can also lead to [metabolic side effects]. This study explores the potential link between [proteasome gene regulation] and [hyperlipidemia] induced by [protease inhibitors (PIs)]. The researchers used a [rat model] to examine the effects of [PIs] on [proteasomal subunit gene expression] in the liver. They found that [treatment of rats with ritonavir results in increases in the expression of proteasomal subunit genes in the liver] and that [this increase is similar in rats treated with bortezomib, a proteasome inhibitor]. Their findings suggest a potential mechanism for [PI-induced hyperlipidemia] and may guide the development of [novel PIs] with fewer [metabolic side effects].
A New Pathway: Proteasome Gene Regulation and HIV Treatment
This research sheds light on a potential mechanism for [hyperlipidemia] associated with [PI] use. The findings suggest that [proteasome gene regulation] may play a role in this adverse effect. This understanding can inform the development of [novel PIs] with improved [metabolic profiles].
Navigating the Desert of Metabolic Side Effects: Proteasome Gene Regulation and HIV Treatment
Imagine a camel navigating a desert, facing the challenges of harsh environmental conditions and potential health risks. This research explores the potential of [proteasome gene regulation] to play a role in the [metabolic side effects] associated with [PI] use. The findings highlight the need for a deeper understanding of these mechanisms to develop safer and more effective [HIV] treatment options.
Dr.Camel's Conclusion
This study offers a new perspective on the [metabolic side effects] associated with [PI] use. The findings suggest that [proteasome gene regulation] may be a crucial factor in understanding and mitigating these adverse effects. Just as a camel adapts to the desert's changing conditions, we can adapt to the challenges of [HIV] treatment by understanding these complex mechanisms and developing innovative solutions for a better future.
Date :
- Date Completed 2010-04-09
- Date Revised 2020-12-09
Further Info :
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