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Effects of the selective alpha 1a-adrenoceptor antagonist silodosin on ECGs of healthy men in a randomized, double-blind, placebo- and moxifloxacin-controlled study.
Author: HillL A, HoelG, LeporH, MorganrothJ, VolinnW
Original Abstract of the Article :
In order to determine the effects of therapeutic and supratherapeutic doses of silodosin on QT interval, healthy men (N = 186; aged 18-45 years) were randomized to receive silodosin (8 or 24 mg) or placebo for 5 days or moxifloxacin 400 mg (positive control, known to prolong QT) once on day 5. At ba...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元:
https://doi.org/10.1038/clpt.2009.265
データ提供:米国国立医学図書館(NLM)
Silodosin: A Safe and Effective Treatment for Benign Prostatic Hyperplasia?
The field of urology is constantly searching for safe and effective treatments for conditions like benign prostatic hyperplasia (BPH). This study investigates the effects of silodosin, an alpha 1a-adrenoceptor antagonist, on the heart. The researchers wanted to know if silodosin, a commonly prescribed medication for BPH, has any negative impact on the electrical activity of the heart. They conducted a randomized, double-blind study, comparing silodosin to a placebo and a known QT-prolonging drug, moxifloxacin. This is like carefully navigating a desert landscape, ensuring that each step doesn't lead to unintended consequences.
Silodosin: No Significant Impact on Heart Rhythm
The study revealed that silodosin had no significant impact on heart rate or QT interval, even at higher doses. This is reassuring for patients taking silodosin for BPH, indicating that it is a safe and effective treatment option. It's like discovering a reliable oasis in a desert, offering a safe haven for patients seeking relief from BPH without compromising their heart health.
A Safe Oasis for Benign Prostatic Hyperplasia
This study provides valuable information for both patients and doctors, demonstrating that silodosin is a safe and effective treatment option for BPH. It's like finding a well-established oasis in the heart of a desert, offering a safe and reliable source of relief for those seeking treatment for BPH.
Dr.Camel's Conclusion
This study offers a reassuring conclusion for those seeking treatment for BPH. Silodosin is a safe and effective option, with no significant impact on heart rhythm. It's like discovering a soothing oasis in the vast desert of BPH treatments, offering a safe and reliable source of relief.
Date :
- Date Completed 2010-05-03
- Date Revised 2018-12-01
Further Info :
Related Literature
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