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Effect of histamine H2 receptor antagonism on levodopa-induced dyskinesia in the MPTP-macaque model of Parkinson's disease.

Author: BrotchieJonathan M, FoxSusan H, JohnstonTom H, van der MeijAnne

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study assessed the ability of famotidine to treat levodopa-induced dyskinesia and wearing off in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-macaque model of PD. Famotidine, at a dose of 3 mg/kg, enhanced the peak-dose anti-parkinsonian actions and extended total duration of action of a low dose of levodopa.
Paper Details　
Original Abstract of the Article :
Levodopa-induced motor complications, including dyskinesia and wearing off, are troublesome side effects of treatment and impair quality of life in Parkinson's disease (PD) patients. The use of nondopaminergic agents as adjuncts to levodopa are potential options for managing these problems. Here, we...See full text at original site
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引用元：
https://doi.org/10.1002/mds.23069

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2010-12-02
  2. Date Revised 2022-05-23
Further Info :

Pubmed ID

20310030

DOI: Digital Object Identifier

10.1002/mds.23069

Related Literature

Article Analysis
・Side Effects of famotidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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