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Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs.

Author: AgemyLilach, GreenwaldDaniel R, KarmaliPriya Prakash, KotamrajuVenkata Ramana, RuoslahtiErkki, SugaharaKazuki N, TeesaluTambet

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study explores the use of a tumor-penetrating peptide, iRGD, to enhance the delivery of anticancer drugs to tumors. iRGD improved the therapeutic index of various drugs, suggesting it may be a valuable tool for improving cancer therapy.
Paper Details　
Original Abstract of the Article :
Poor penetration of anticancer drugs into tumors can be an important factor limiting their efficacy. We studied mouse tumor models to show that a previously characterized tumor-penetrating peptide, iRGD, increased vascular and tissue permeability in a tumor-specific and neuropilin-1-dependent manner...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/20378772

データ提供：米国国立医学図書館（NLM）

Improving Cancer Drug Efficacy with Tumor-Penetrating Peptides

One of the challenges in cancer treatment is the limited penetration of anticancer drugs into tumors. This study investigates the potential of a tumor-penetrating peptide, iRGD, to enhance the efficacy of cancer drugs by increasing vascular and tissue permeability within the tumor. The researchers studied mouse tumor models and found that iRGD improved the therapeutic index of various drugs, including small molecules, nanoparticles, and a monoclonal antibody.

Boosting Cancer Drug Effectiveness with iRGD

This research provides promising evidence for the potential of iRGD, a tumor-penetrating peptide, to enhance the efficacy of cancer drugs. The authors demonstrate that iRGD increases vascular and tissue permeability in tumors, allowing coadministered drugs to reach extravascular tumor tissue more effectively. This could lead to more targeted and effective cancer treatments.

Think About It Like a Desert Oasis

Imagine a desert oasis, providing a haven for weary travelers. Similarly, iRGD, a tumor-penetrating peptide, acts like a guide, leading cancer drugs to their target, the tumor. By increasing vascular and tissue permeability, iRGD helps to deliver drugs more effectively to the tumor, potentially improving treatment outcomes.

Dr.Camel's Conclusion

This study highlights the potential of iRGD, a tumor-penetrating peptide, to enhance the efficacy of cancer drugs. The authors' findings suggest that iRGD could improve the therapeutic index of a range of drugs, offering hope for more effective and targeted cancer treatments.

Date :
  1. Date Completed 2010-06-02
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

20378772

DOI: Digital Object Identifier

NIHMS200073

SNS
PICO Info
in preparation
Languages

English

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