Effect of dienogest on estrogen-induced nitric oxide production in human umbilical vein endothelial cells and endothelium-dependent vasodilatation in postmenopausal women.

Author: AmitaMitsuyoshi, HenmiNoriko, KurachiHirohisa, OhtaTsuyoshi, TakahashiKazuhiro, TakahashiToshifumi, TakataKeiko, TsutsumiSeiji

Paper Details 
Original Abstract of the Article :
OBJECTIVE: We investigated the effects of dienogest (DNG), which has a profile similar to that of natural progesterone (P4), on the favorable effects of estrogen in endothelial function. METHODS: (1) Human umbilical vein endothelial cells were treated with medroxyprogesterone acetate (MPA), DNG, or...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1097/gme.0b013e3181d273c7

データ提供:米国国立医学図書館(NLM)

The Benefits of Dienogest for Women's Health

Menopause is a natural transition for women, a journey through the desert of hormonal changes. This research explores the effects of dienogest, a medication similar to natural progesterone, on endothelial function in postmenopausal women.

The study investigated the effects of dienogest on estrogen-induced nitric oxide production in human umbilical vein endothelial cells and endothelium-dependent vasodilatation in postmenopausal women. It's like exploring the impact of different desert plants on the oasis's water sources, understanding how they affect the ecosystem's health.

The study found that dienogest, unlike medroxyprogesterone acetate, did not inhibit the positive effects of estrogen on endothelial function, leading to improved vasodilatation. This is like finding a desert plant that not only doesn't harm the oasis's water source but also enhances its vitality.

A New Oasis for Women's Health

This research offers promising implications for women's health, suggesting that dienogest may be a beneficial option for hormone therapy during menopause, potentially improving endothelial function and cardiovascular health. It's like discovering a new oasis that provides not only refreshment but also enhanced vitality and resilience.

A Healthier Journey Through Menopause

The study emphasizes the importance of understanding the complex interplay of hormones and their impact on women's health. It's like navigating the desert of menopause, equipped with knowledge and tools to navigate the challenges and find a path to a healthier and more fulfilling life.

Dr. Camel's Conclusion

This research sheds light on the potential benefits of dienogest for women's health, suggesting it could be a valuable tool for managing the challenges of menopause. It's like finding a new oasis in the desert of hormonal changes, a place where women can find balance and well-being.

Date :
  1. Date Completed 2010-08-06
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

20386344

DOI: Digital Object Identifier

10.1097/gme.0b013e3181d273c7

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.