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Preferential increase in memory and regulatory subsets during T-lymphocyte immune reconstitution after Thymoglobulin induction therapy with maintenance sirolimus vs cyclosporine.

Author: BadetLionel, BessonCaroline, BrunetMaria, LefrançoisNicole, MalcusChristophe, MorelonEmmanuel, PrévautelJulie, ThaunatOlivier, TouraineJean-Louis, Touraine-MoulinFrançoise

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Sirolimus therapy following Thymoglobulin induction in kidney transplant patients resulted in disproportionately high recovery of memory T-lymphocyte subsets, which may explain the higher rejection rate seen with sirolimus compared to cyclosporine.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Sirolimus maintenance therapy with Thymoglobulin induction is a promising regimen that may preserve renal function. Data are lacking, however, about the immunologic effects of combined Thymoglobulin-sirolimus. METHODS: In a 12-month, prospective, randomised, open-label, single-centre pi...See full text at original site
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引用元：
https://doi.org/10.1016/j.trim.2010.04.004

データ提供：米国国立医学図書館（NLM）

Immune Reconstitution: A Tale of Two Immunosuppressants

Kidney transplantation, a life-saving procedure for individuals with kidney failure, often involves a complex interplay of immunosuppressants to prevent rejection. This research compares the immunologic effects of two maintenance immunosuppressants, sirolimus and cyclosporine, following Thymoglobulin induction therapy in kidney transplant recipients.

Sirolimus vs. Cyclosporine: A Journey Through Immune Reconstitution

The research, comparing sirolimus and cyclosporine maintenance therapy after Thymoglobulin induction, reveals differences in immune reconstitution patterns. Sirolimus is associated with a slower reconstitution of CD4+ T-lymphocytes but a preferential increase in memory and regulatory T-lymphocyte subsets. Imagine navigating a desert with two different guides – each guide leads to a different destination, with unique advantages and disadvantages. This research highlights the different paths of immune reconstitution with sirolimus and cyclosporine.

Navigating the Desert of Immunosuppression: Understanding the Landscape

This research underscores the importance of understanding the individual effects of different immunosuppressants on immune reconstitution. It highlights the need for personalized approaches to immunosuppression, taking into account the patient's specific immune status and the potential impact of different medications. Like a desert traveler carefully choosing their route, clinicians need to consider the nuances of different immunosuppressants to optimize patient outcomes.

Dr.Camel's Conclusion

This research on immune reconstitution after kidney transplantation reminds me of a desert with diverse landscapes and challenging paths. It highlights the importance of understanding the complex interactions between immunosuppressants and the immune system. This research provides valuable insights for clinicians to navigate the intricate terrain of immunosuppression and optimize patient care, ultimately leading to better long-term outcomes for kidney transplant recipients.

Date :
  1. Date Completed 2010-10-14
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

20406686

DOI: Digital Object Identifier

10.1016/j.trim.2010.04.004

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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