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[Clinical studies on the utility of ofloxacin for lower respiratory infections].

Author: IshimaruT, KashiwagiS, KumagaiY, KuwabaraK, MuranishiT, NagafuchiS, SawaeY, ShigeokaH, TakiiM, TakitaA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Twice-daily administration of ofloxacin (OFLX) was more effective at 400 mg than 600 mg daily in treating lower respiratory tract infections. The 400 mg group had better clinical symptom improvement, a higher rate of bacterial eradication, and fewer side effects. However, the 600 mg group had a slightly higher rate of significant symptom amelioration.
Paper Details　
Original Abstract of the Article :
One hundred and thirteen patients who were treated at the Kyushu University Hospital and other related hospitals were randomly assigned to 2 groups to compare the effect of twice daily administration of 200 mg each and that of 300 mg each of ofloxacin (OFLX). The patients included 41 cases with pneu...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2041147

データ提供：米国国立医学図書館（NLM）

Ofloxacin for Lower Respiratory Infections: Finding the Right Dose

This study delves into the fascinating world of respiratory infections and explores the efficacy of ofloxacin, a powerful antibiotic, in treating lower respiratory infections. The researchers compared the effectiveness of two different doses of ofloxacin, 400mg and 600mg, administered twice daily. They found that a lower dose (400mg) was more effective in improving clinical symptoms and reducing the number of bacteria in the patients. Interestingly, they observed that the higher dose was associated with more side effects, particularly central nervous system symptoms like sleeplessness. It's like a camel traversing a desert with a heavy load - too much weight can lead to fatigue and discomfort. The researchers concluded that the 400mg dose was the most effective treatment for lower respiratory infections.

Optimal Dosing for Effective Treatment

This study sheds light on the importance of finding the right dose for effective treatment. While higher doses may seem like a faster solution, the researchers found that a lower dose of ofloxacin was more effective and less prone to side effects. It's like a camel traveling through the desert - a lighter load allows for greater speed and endurance.

Navigating the Desert of Respiratory Infections

Understanding the right dose of medications is crucial for optimal treatment of respiratory infections. This study emphasizes the need to carefully consider the potential side effects of medications, particularly when it comes to higher doses. It's like a camel navigating the desert - knowing the limitations of its endurance and choosing a path that minimizes the risk of dehydration and exhaustion.

Dr.Camel's Conclusion

This study serves as a reminder that more is not always better when it comes to medication. The optimal dose for treatment can vary depending on the specific condition, and careful consideration should be given to potential side effects. Finding the right balance is crucial for a successful journey through the desert of illness.

Date :
  1. Date Completed 1991-07-08
  2. Date Revised 2016-11-16
Further Info :

Pubmed ID

2041147

DOI: Digital Object Identifier

2041147

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Languages

Japanese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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