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Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models.
Author: AtsumiIkuyo, FujiiAtsuko, IemuraMasahito, KidaTetsuo, SakaiOsamu, SakakiHideyuki, WadaTomoyuki
Original Abstract of the Article :
To elucidate the ocular pharmacological properties of bepotastine besilate, a selective histamine H(1) receptor antagonist, when compared with other histamine H(1) receptor antagonists, using guinea pig allergic conjunctivitis models and in vitro models of eosinophil recruitment and mast cell membra...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.exer.2010.04.006
データ提供:米国国立医学図書館(NLM)
Bepotastine Besilate: A Multifaceted Agent for Allergic Conjunctivitis
Navigating the vast desert of allergies can be a challenging experience, often leaving us with itchy, watery eyes. This research explores the potential of bepotastine besilate, a highly selective histamine H1 receptor antagonist, in the treatment of allergic conjunctivitis, a common eye allergy. Researchers used various in vitro and in vivo models of allergic conjunctivitis to compare bepotastine besilate to other antihistamines. They found that bepotastine besilate significantly inhibited conjunctival vascular hyperpermeability and eosinophil recruitment, demonstrating its effectiveness in reducing allergy symptoms. Bepotastine besilate also showed a stronger effect than other antihistamines in suppressing eosinophil infiltration and histamine release, indicating its potential to provide more comprehensive allergy relief.
A Multifaceted Approach to Allergy Relief
This research suggests that bepotastine besilate could be a promising treatment for allergic conjunctivitis. It effectively blocks histamine H1 receptors, reduces vascular permeability, and inhibits eosinophil recruitment, offering a multifaceted approach to combat allergy symptoms. Its superior efficacy compared to other antihistamines suggests its potential to provide more comprehensive relief for those with this condition.
Managing Eye Allergies
Allergic conjunctivitis can be a nuisance, but finding the right treatment can make a world of difference. This research highlights the potential of bepotastine besilate to provide effective relief from allergy symptoms. Consult with an eye care professional to discuss your specific allergy needs and explore the best treatment options available.
Dr.Camel's Conclusion
Just like a camel navigating through a desert of pollen and allergens, finding relief from allergic conjunctivitis can be a challenging journey. This research provides promising insights into the potential of bepotastine besilate to offer comprehensive relief from eye allergy symptoms. Don't forget to consult an eye care professional for personalized advice and treatment options.
Date :
- Date Completed 2010-06-22
- Date Revised 2017-11-16
Further Info :
Related Literature
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