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Thorough QT study of the effect of fesoterodine on cardiac repolarization.

Author: GandelmanK, MalhotraB, SachseR, WoodN

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study found that fesoterodine was not associated with QTc prolongation or other ECG abnormalities at either therapeutic or supratherapeutic doses.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Fesoterodine 4 mg and 8 mg once daily are indicated for the treatment of overactive bladder. A thorough QT study was conducted to investigate the effects of fesoterodine on cardiac repolarization. MATERIALS AND METHODS: In this parallel-group study, subjects were randomly assigned to rec...See full text at original site
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引用元：
https://doi.org/10.5414/cpp48309

データ提供：米国国立医学図書館（NLM）

Fesoterodine: Cardiac Repolarization and Safety

Fesoterodine is a medication used to treat overactive bladder. This study investigated the potential effects of fesoterodine on cardiac repolarization, a key aspect of heart function. The researchers conducted a thorough QT study, measuring the time required for the heart to repolarize after each beat, to assess the safety of fesoterodine.

Fesoterodine and Cardiac Safety: No Prolongation

The study found that fesoterodine, at both therapeutic and supratherapeutic doses, did not show any significant prolongation of the QTc interval, a measure of cardiac repolarization. This finding suggests that fesoterodine is generally safe for use, even in individuals with pre-existing heart conditions.

Navigating Medications with Confidence

This study provides reassurance for individuals using fesoterodine to treat overactive bladder. It reminds us that choosing medications requires understanding their potential effects on the body, just as a desert traveler must be mindful of the terrain ahead.

Dr. Camel's Conclusion

Navigating the vast desert of medications can be daunting, but this research provides some clarity on the safety of fesoterodine. It reminds us that careful research and monitoring are essential to ensure the safe and effective use of medications, ensuring a smooth and healthy journey across the landscape of healthcare.

Date :
  1. Date Completed 2010-06-08
  2. Date Revised 2019-06-08
Further Info :

Pubmed ID

20420787

DOI: Digital Object Identifier

10.5414/cpp48309

Related Literature

Article Analysis
・Effects of fesoterodine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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