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Effect of mipomersen, an apolipoprotein B synthesis inhibitor, on low-density lipoprotein cholesterol in patients with familial hypercholesterolemia.
Author: AkdimFatima, BakerBrenda F, FlaimJoann D, KasteleinJohn J P, SteinEvan A, StroesErik S G, SuJohn, TribbleDiane L, VisserMaartje E, YuRosie
Original Abstract of the Article :
A randomized, double-blind, placebo-controlled, dose-escalation study was conducted to examine the efficacy and safety of mipomersen (ISIS 301012), an antisense inhibitor of apolipoprotein B, when added to conventional lipid-lowering therapy for patients with heterozygous familial hypercholesterolem...See full text at original site
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引用元:
https://doi.org/10.1016/j.amjcard.2010.01.003
データ提供:米国国立医学図書館(NLM)
Mipomersen: A New Frontier in Lowering LDL Cholesterol
This randomized, double-blind, placebo-controlled study investigates the efficacy and safety of [mipomersen], an antisense inhibitor of apolipoprotein B, in patients with [heterozygous familial hypercholesterolemia]. The study demonstrates that mipomersen, when added to conventional lipid-lowering therapy, significantly reduces [low-density lipoprotein (LDL) cholesterol] levels, a key factor in cardiovascular disease risk.
A New Weapon in the Fight Against High Cholesterol: Mipomersen Shows Promise
The study's findings, like a beacon of hope in the desert of cardiovascular disease, show that mipomersen can significantly lower LDL cholesterol levels, a major risk factor for heart disease. The study's rigorous methodology, with its dose-escalation design and careful safety monitoring, provides compelling evidence for the potential of this new treatment. The study's findings could pave the way for [more effective treatment strategies] for individuals with familial hypercholesterolemia.
Navigating the Landscape of Cardiovascular Risk: Mipomersen Offers New Possibilities
This research, like a map guiding us through the complex landscape of cardiovascular risk, sheds light on a new therapeutic option for managing high cholesterol. The study's findings highlight the importance of [ongoing research and development] in the field of [cardiovascular medicine], with the goal of identifying new and effective treatments to combat heart disease. The potential of mipomersen, like a refreshing oasis in the vast desert of cardiovascular challenges, offers hope for a healthier future for millions.
Dr.Camel's Conclusion
Mipomersen, like a new breed of camel capable of navigating even the most treacherous terrain, holds promise in the fight against high cholesterol. This study, like a well of knowledge in the vast desert of cardiovascular research, provides valuable insights into the potential of this new treatment. The research's findings, like a flickering candle in the darkness, offer hope for a brighter future for those struggling with familial hypercholesterolemia.
Date :
- Date Completed 2010-06-01
- Date Revised 2012-11-15
Further Info :
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