Paper Details

  1. Home
  2. Paper Details

Strain-related effects of fenbendazole treatment on murine experimental autoimmune encephalomyelitis.

Author: HallC, OrianJ M, RampA A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Pinworms are effectively controlled with the anthelminthic fenbendazole (FBZ), but long-term exposure may influence the course of certain diseases. This study investigated the effect of a three-month FBZ regimen on murine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. FBZ significantly affected the onset and severity of EAE, with differences observed between mouse strains. These findings suggest that the full effects of FBZ on specific EAE variants should be considered when using this drug in research.
Paper Details　
Original Abstract of the Article :
Parasitic infections are a concern in animal facilities, in view of their influence on physiological processes and the immune status of animals. Pinworms are effectively controlled with the anthelminthic fenbendazole (FBZ, [5-(phenylthio)-1H-benzamidazol-2-yl]carbamic acid methyl ester; C(15)H(13)N(...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1258/la.2010.009148

データ提供：米国国立医学図書館（NLM）

Fenbendazole: A Complex Impact on Autoimmune Disease

Greetings from Dr. Camel, your guide to the complex interplay between [parasitic infections] and [autoimmune diseases]. This research delves into the effects of fenbendazole (FBZ), an anthelminthic drug used to control pinworms, on the course of murine experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis. The study revealed a complex interaction between FBZ, parasitic infection, and autoimmune disease, highlighting the importance of considering the full impact of medications, especially when treating chronic conditions. The researchers found that a prolonged regimen of FBZ significantly affected the onset and severity of EAE, with varying effects depending on the mouse strain. This finding underscores the importance of considering the potential impact of medications on the immune system, particularly in the context of autoimmune diseases. It's like navigating a desert landscape where a seemingly harmless plant can have unexpected consequences depending on the surrounding environment.

A Complex Desert Landscape

This research underscores the complex interplay between parasitic infections, autoimmune diseases, and medications like FBZ. The varying effects of FBZ on different mouse strains highlight the importance of considering the individual characteristics of each patient and their specific health conditions. It's like navigating a desert landscape, where the terrain and resources can vary significantly, requiring careful consideration and adaptation.

Navigating the Desert of Autoimmune Disease

This study emphasizes the need for caution when considering the use of medications for parasitic infections in patients with autoimmune diseases. It highlights the importance of considering the potential impact of medications on the immune system and the need for personalized treatment approaches. It's a reminder that navigating the desert of autoimmune disease requires careful consideration and a deep understanding of the intricate factors at play.

Dr. Camel's Conclusion

This research illustrates the intricate interplay between parasitic infections, autoimmune diseases, and medication. It's a reminder that even seemingly simple interventions can have complex and unexpected consequences, underscoring the importance of personalized medicine and a thorough understanding of the patient's individual circumstances. It's like navigating a vast and complex desert landscape, requiring careful consideration, adaptability, and a deep understanding of the terrain.

Date :
  1. Date Completed 2010-09-28
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

20457828

DOI: Digital Object Identifier

10.1258/la.2010.009148

Related Literature

Article Analysis
・Effective treatment of pinworms
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.