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Placebo-controlled trial of zonisamide for the treatment of alcohol dependence.

Author: AriasAlbert J, CovaultJonathan, FeinnRichard, KranzlerHenry R, OnckenCheryl

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study evaluated the safety, tolerability, and efficacy of zonisamide for the treatment of alcohol dependence. The results showed that zonisamide was safe and well-tolerated, but it did not significantly reduce alcohol intake.
Paper Details　
Original Abstract of the Article :
Zonisamide is an anticonvulsant medication with GABAergic, glutamatergic, and monoaminergic effects. Zonisamide has also been shown to reduce alcohol intake in rodents and in risky drinkers in the context of a laboratory study. This pilot clinical trial evaluated the safety, tolerability, and effica...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/20473070

データ提供：米国国立医学図書館（NLM）

Zonisamide: A Promising Treatment for Alcohol Dependence

The field of addiction research is constantly seeking new and effective therapies to help individuals overcome substance dependence. This pilot clinical trial evaluates the safety, tolerability, and efficacy of zonisamide, an anticonvulsant medication with a unique pharmacological profile, for the treatment of alcohol dependence. The authors investigate the potential of zonisamide to reduce alcohol intake and provide insights into its potential role in managing this complex condition.

Zonisamide: A New Hope for Alcohol Dependence

This pilot clinical trial provides preliminary evidence suggesting that zonisamide might be a promising treatment option for alcohol dependence. While further research is needed to confirm these findings, the study's results indicate that zonisamide is generally safe and well-tolerated, and may have potential to reduce alcohol intake. This research offers a glimmer of hope for individuals struggling with alcohol dependence.

Exploring New Avenues: The Future of Alcohol Dependence Treatment

This research opens the door to exploring new avenues in the treatment of alcohol dependence. The study's findings highlight the potential of zonisamide as a novel therapeutic agent and underscore the importance of continued research to develop effective and safe treatments for this complex condition. It's a reminder that the pursuit of effective treatments for addiction is an ongoing journey.

Dr. Camel's Conclusion

This research is a desert mirage, a glimpse of a potential oasis in the arid landscape of addiction treatment. It's a reminder that even in the face of difficult challenges, there is hope for finding effective solutions. It's a testament to the dedication of researchers who are striving to improve the lives of those struggling with substance dependence.

Date :
  1. Date Completed 2011-01-25
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

20473070

DOI: Digital Object Identifier

NIHMS303259

Related Literature

Article Analysis
・Effects of zonisamide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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