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NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy.

Author: Gómez-SintesRaquel, LucasJosé J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Lithium is a drug that is used to treat bipolar disorder. This study investigated the effects of lithium on brain cells in mice. The study found that lithium can cause brain cell death in mice. The study also found that this cell death is caused by a specific protein pathway.
Paper Details　
Original Abstract of the Article :
Use of lithium, the mainstay for treatment of bipolar disorder, is limited by its frequent neurological side effects and its risk for overdose-induced toxicity. Recently, lithium has also been proposed as a treatment for Alzheimer disease and other neurodegenerative conditions, but clinical trials h...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898581/

データ提供：米国国立医学図書館（NLM）

Lithium Therapy: Exploring the Desert's Hidden Depths

Lithium, a mainstay in the treatment of bipolar disorder, is a powerful tool with complex effects. Imagine lithium as a deep oasis, offering a calming respite but also harboring hidden currents. This research explores the potential mechanisms underlying both the beneficial and adverse effects of lithium, particularly focusing on its impact on neuronal apoptosis and motor side effects.

Unveiling the Secrets of Lithium's Effects

The research delves into the intricate relationship between lithium and neuronal apoptosis, investigating the role of GSK-3 inhibition and NFAT/Fas signaling. It's like peering into the depths of a desert oasis, seeking to understand the intricate workings of this powerful substance. The authors uncover a complex interplay between lithium, GSK-3, NFAT, and Fas, suggesting that lithium's potential benefits may be accompanied by a risk of neuronal loss and motor deficits.

Navigating the Landscape of Lithium Therapy

This research highlights the importance of understanding the potential risks and benefits of lithium therapy. It's like a desert traveler venturing into uncharted territory, aware of both the beauty and dangers that lie ahead. The findings suggest a need for careful monitoring and potential strategies to mitigate the adverse effects of lithium while maximizing its therapeutic potential.

Dr.Camel's Conclusion

This research delves into the complex landscape of lithium therapy, revealing the intricate interplay between this powerful drug and the nervous system. Like a seasoned desert explorer, we must carefully study the potential benefits and risks of lithium, ensuring its safe and effective use for those who need it most.

Date :
  1. Date Completed 2010-07-27
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

20530871

DOI: Digital Object Identifier

PMC2898581

Related Literature

Article Analysis
・Side Effects of lithium
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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