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Characterization of skeletal muscle effects associated with daptomycin in rats.
Author: ColemanScott, DavisCarol, FaulknerJohn A, HassettCheryl A, KostrominovaTatiana Y, LarkinLisa M, OlesonFrederick B, RaderErik P
Original Abstract of the Article :
Daptomycin is a lipopeptide antibiotic with strong bactericidal effects against Gram-positive bacteria and minor side effects on skeletal muscles. The type and magnitude of the early effect of daptomycin on skeletal muscles of rats was quantified by histopathology, examination of contractile propert...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1002/mus.21691
データ提供:米国国立医学図書館(NLM)
Daptomycin: A Powerful Antibiotic with Muscle-Related Side Effects
Daptomycin is a powerful antibiotic used to treat serious bacterial infections. This research investigates the potential muscle-related side effects of daptomycin in rats, providing valuable insights into the mechanisms and severity of these effects. The researchers aim to understand the impact of daptomycin on muscle function and identify potential strategies for minimizing these side effects.
Muscle Effects of Daptomycin: A Closer Look
The researchers discovered that daptomycin can have a significant impact on muscle function, with evidence of muscle fiber damage and inflammation. This finding is like a desert traveler encountering a treacherous path, leading to injury and potential complications. However, the researchers also found that the effects were dose-dependent, suggesting that careful monitoring and dosage adjustments may help minimize these risks.
Navigating the Landscape: Understanding the Potential Risks
This research highlights the importance of understanding the potential side effects of medications, even those offering significant benefits. It emphasizes the need for careful monitoring and dose adjustments, particularly in individuals at risk for muscle-related complications. It's like navigating a desert with potentially hazardous terrain; awareness and careful planning are crucial for a safe journey.
Dr.Camel's Conclusion
This research provides valuable information about the potential muscle-related side effects of daptomycin, reminding us that even with potent therapeutic agents, careful monitoring and management are essential. It's a journey through the desert of drug development, where understanding the full spectrum of effects is crucial for ensuring patient safety and optimizing treatment outcomes.
Date :
- Date Completed 2010-09-16
- Date Revised 2013-11-21
Further Info :
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