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Bisphosphonate protonation states, conformations, and dynamics on bone mineral probed by solid-state NMR without isotope enrichment.

Author: ByardStephen, DuerMelinda J, IronsideMatthew S, ReidDavid G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Bisphosphonates are drugs that are used to treat osteoporosis and other bone disorders. This study investigated the ways in which bisphosphonates bind to bone mineral. The study found that bisphosphonates bind to bone mineral in a way that is dependent on their molecular structure and flexibility.
Paper Details　
Original Abstract of the Article :
Recognition of bone mineral by bisphosphonates is crucial to their targeting, efficacy, therapeutic and diagnostic applications, and pharmacokinetics. In a search for rapid and simple NMR approaches to assessing the bone recognition characteristics of bisphosphonates, we have studied alendronate, pa...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejpb.2010.05.013

データ提供：米国国立医学図書館（NLM）

Bisphosphonates and Bone Mineral: A Camel's Journey Through the Desert of Bone Biology

The field of bone biology is a vast desert, filled with intricate pathways and complex interactions. Bisphosphonates, a class of drugs used to treat osteoporosis and other bone disorders, target bone mineral to exert their therapeutic effects. This study investigates the binding characteristics of bisphosphonates to bone mineral using solid-state NMR spectroscopy. Researchers analyzed the protonation states, conformations, and dynamics of various bisphosphonates in crystalline form and bound to bone mineral. Their findings indicated that all mineral-bound bisphosphonates displayed similar characteristics to deprotonated phosphonates, providing insights into the mechanism of bisphosphonate action.

A Closer Look at the Bone Desert

This research offers a deeper understanding of the interaction between bisphosphonates and bone mineral. The study's findings provide valuable insights into the mechanism of bisphosphonate action, which could lead to the development of more effective treatments for bone disorders.

Exploring the Desert: A Camel's Perspective on Bone Health

This research reminds us of the complex nature of bone biology. The study's findings highlight the importance of understanding the intricate interactions between drugs and bone mineral. By unraveling these mysteries, we can develop more effective treatments for a wide range of bone disorders.

Dr. Camel's Conclusion

This research offers a deeper understanding of bisphosphonate action and their interaction with bone mineral. The study's findings provide valuable insights that could lead to the development of more effective and targeted treatments for bone disorders. As Dr. Camel, I am always seeking knowledge that can improve the lives of others, and this research is a step in the right direction.

Date :
  1. Date Completed 2010-12-07
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

20554022

DOI: Digital Object Identifier

10.1016/j.ejpb.2010.05.013

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Languages

English

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