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Activity of antiandrogens against juvenile and adult Schistosoma mansoni in mice.

Author: KeiserJennifer, VargasMireille, VennerstromJonathan L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The antiandrogen nilutamide showed promising antischistosomal properties in both in vivo and in vitro studies. In mice infected with Schistosoma mansoni, nilutamide reduced total worm burden by 85% and female worm burden by 71%. A combination of nilutamide and praziquantel also demonstrated significant worm burden reductions. In vitro, cyproterone acetate killed schistosomes within 15 hours, while bicalutamide, nilutamide, and flutamide reduced the movement of adult worms.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: The antischistosomal properties of the marketed antiandrogens bicalutamide, flutamide, nilutamide and cyproterone acetate were studied both in vivo and in vitro. METHODS: Schistosoma mansoni-infected mice were treated orally with 50-400 mg/kg of the antiandrogens 3 and 7 weeks post-infe...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920177/

データ提供：米国国立医学図書館（NLM）

Exploring the Antischistosomal Properties of Antiandrogens

This research delves into the fascinating world of parasitic diseases, specifically focusing on schistosomiasis, a debilitating infection caused by parasitic worms. The study investigates the antischistosomal properties of four marketed antiandrogens, namely bicalutamide, flutamide, nilutamide, and cyproterone acetate, both in vivo and in vitro. This research aims to evaluate the potential of these drugs as novel anti-schistosomal agents, offering a potential new avenue for treating this widespread and neglected tropical disease.

Antiandrogens as Potential Antischistosomal Agents

The research findings suggest that nilutamide, a hydantoin derivative, exhibits promising antischistosomal properties, particularly against adult Schistosoma mansoni. The study observed significant reductions in worm burden following nilutamide treatment, both alone and in combination with praziquantel. These findings highlight the potential of nilutamide as a novel anti-schistosomal agent, warranting further investigation and development.

Seeking New Solutions for Schistosomiasis

This research underscores the importance of exploring new and effective treatment options for schistosomiasis, a disease that affects millions of people worldwide. It highlights the potential of repurposing existing drugs, such as antiandrogens, for treating parasitic infections. The study's findings provide valuable insights into the potential of nilutamide as an antischistosomal agent, offering hope for developing new and effective therapies for this neglected tropical disease.

Dr.Camel's Conclusion

This study reminds me of the interconnectedness of different fields of medicine and the potential for unexpected discoveries. Just like a camel traversing the desert, this research explores uncharted territory, seeking new solutions for a neglected disease. The study's findings highlight the potential of repurposing existing drugs for new therapeutic applications, inspiring continued exploration and innovation in the fight against parasitic infections.
Date :
  1. Date Completed 2010-11-16
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

20576641

DOI: Digital Object Identifier

PMC2920177

Related Literature

Article Analysis
・Effects of nilutamide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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