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Tamoxifen enhances the cytotoxic effects of nelfinavir in breast cancer cells.

Author: BrüningAnsgar, BurgesAlexander, FrieseKlaus, MylonasIoannis

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The HIV protease inhibitor nelfinavir induces cell cycle arrest, endoplasmic reticulum stress, autophagy, and apoptosis in cancer cells, suggesting potential anti-cancer activity.
Paper Details　
Original Abstract of the Article :
The HIV protease inhibitor nelfinavir is currently under investigation as a new anti-cancer drug. Several studies have shown that nelfinavir induces cell cycle arrest, endoplasmic reticulum stress, autophagy, and apoptosis in cancer cells. In the present article, the effect of nelfinavir on human br...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949632/

データ提供：米国国立医学図書館（NLM）

Synergy in Cancer Treatment: Tamoxifen and Nelfinavir

This study explores a promising area of [cancer research] – the investigation of combination therapies for breast cancer. The study examines the potential of combining tamoxifen, a selective estrogen receptor modulator, with nelfinavir, an HIV protease inhibitor, to enhance the cytotoxic effects against breast cancer cells. The researchers found that tamoxifen significantly enhanced the cytotoxic effects of nelfinavir, suggesting that this combination therapy could be a potential approach for treating breast cancer.

Enhanced Cytotoxic Effects with Tamoxifen and Nelfinavir

The findings suggest that combining tamoxifen with nelfinavir could be a more effective approach for treating breast cancer compared to either drug alone. This research highlights the potential of combination therapies in cancer treatment and underscores the need for further investigation to optimize treatment regimens.

Combating Cancer: A Multifaceted Approach

This study underscores the importance of developing innovative and effective treatment strategies for cancer. Exploring combination therapies and understanding the complex interactions between different drugs is crucial for optimizing cancer treatment outcomes. Just like a camel adapts to survive in the desert, combating cancer requires a multifaceted approach.

Dr.Camel's Conclusion

This study explores the potential of combining tamoxifen and nelfinavir for enhanced cytotoxic effects against breast cancer cells. It highlights the importance of developing combination therapies and underscores the need for further research in this area.

Date :
  1. Date Completed 2011-03-01
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

20594311

DOI: Digital Object Identifier

PMC2949632

Related Literature

Article Analysis
・Effects of nelfinavir
SNS
PICO Info
in preparation
Languages

English

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